Lessee Calls for Investigation into House Burning

first_imgA lessee of a three-bedroom house, which was gutted by fire and “completely burnt down” recently in the Paynesville 12 Houses Community, has asked authorities of the Liberian National Police (LNP), the Liberian Electricity Corporation (LEC) and the National Fire Services (NFS) to investigate the blaze.Madam Mariama Kaba, who has just moved into the house this past February, had leased the house for one year and said lease was renewable.She told the Observer via phone recently that on the night the house got burnt she had walked on the road (Tubman Boulevard) to get something (not specific). According to her, before she left, she instructed the security guarding the house to also look after her 10-year-old twin girls, who were in their room playing video games.“While on the road, the security called me and told me that smoke was coming from my room. I ran home and entered the living room. When I opened my door, the whole room was filled with thick black smoke. I told everyone to get out of the house. But by then the fire had already spread to other parts of the house,” Mariama explained.According to her, she was not able to rescue the “tons of belongings” she had in the house and all of them were burnt to ashes.When asked about the cause(s) of the fire, she stated that she could not be certain what had caused the fire, but she could hear bystanders saying that it was the high voltage from the Liberia Electricity Corporation (LEC), which was supplying the house with electricity.Mariama said it was just the second week after she got connected to the LEC supply line and that the current was always “fluctuating,” meaning the current was not stable.According to her, when the fire started, they had called the National Fire Service, “but it took forever” before they got there and when they did, “the house had already burnt to ashes.” No authorities from either of those agencies—LNP, LEC and NFS—could be reached for comments as their phones were either said to be switched off or rang endlessly.Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)last_img read more

Programmed cell death follows a wave pattern killing cells as it moves

first_imgBy Dr. Ananya Mandal, MDAug 10 2018According to a new study from the Stanford University School of Medicine programmed cell death or apoptosis follows a trigger and a ripple effect pattern. James Ferrell, MD, Ph.D., professor of chemical and systems biology and of biochemistry at Stanford explained that cell death regulation starts with a trigger wave and this occurs in cell regulation recurrently. “Sometimes our cells die when we really don’t want them to—say, in neurodegenerative diseases. And sometimes our cells don’t die when we really do want them to—say, in cancer,” Ferrell said. “And if we want to intervene, we need to understand how apoptosis is regulated,” he added. The study titled “Apoptosis propagates through the cytoplasm as trigger waves,” on the details of apoptosis regulation is published in the journal Science this week.Xianrui Cheng, Ph.D., a Postdoctoral scholar led this study where they found that apoptosis spreads across the cytoplasm like wildfire. The speed of movement of this wave is undeterred they noted. The researchers explain it like falling dominoes. The force necessary to trigger the cell apoptosis is all that is needed for it to spread, they noted. Once the waves start there are special proteins called caspases that are activated. These caspases activate other caspases until it has spread to the whole group of cells. Ferrell explained that it spreads “in this fashion and never slows down, never peters out.” “It doesn’t get any lower in amplitude because every step of the way it’s generating its own impetus by converting more inactive molecules to active molecules, until apoptosis has spread to every nook and cranny of the cell,” he said.Related StoriesNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsSlug serves as ‘command central’ for determining breast stem cell healthNanoparticles used to deliver CRISPR gene editing tools into the cellFor their experiment Cheng and Ferrell used Xenopus laevis frog eggs as their experimental cells. Each of the eggs is a single cell. Fluid from the eggs were extracted and inserted into tiny Teflon tubes that are a few millimetres long. Then they initiated the “death signal” and started the cascade of apoptosis. They watched as the apoptosis progressed using fluorescent markers at the rate of 30 micrometers per minute. The bright green light that signified apoptosis movement progressed at a constant speed.Cheng and Ferrell saw that when the eggs died they displayed a dark pigmentation on their surface. As the cells continued to die, the dark pigmentation spread across the cells in a curved line. They noted that the cells dying had activated caspases while the intact cells did not have activated caspases. The waves however travelled to all the cells. Ferrel said that this spread of the trigger waves could be the same way as the immune responses and viruses spread from one cell to another. He called this spread as a “recurring theme” in nature.Source: http://science.sciencemag.org/content/361/6402/607 Cell apoptosis, a process of programmed cell destruction that occurs in multicellular organisms, 3D illustration showing changes in cellular morphology, blebbing, cell shrinkage. Image Credit: Kateryna Kon / Shutterstocklast_img read more