Those conspiring for President’s Rule in Maharashtra are insulting people’s mandate: Sanjay Raut

first_imgSenior Shiv Sena leader Sanjay Raut on Wednesday claimed there was a “consensus” between the BJP and his party before the Maharashtra Assembly elections on sharing the chief minister’s post.Amid the stalemate continuing over government formation in the state, Mr. Raut told reporters here that no fresh proposal has been received from the BJP or sent to it.He claimed farmers and the working class want a Shiv Sena chief minister and have hopes and expectations from the Uddhav Thackeray-led party.To a question on when there would be a consensus on the chief minister’s post, the Rajya Sabha member said, “There was a consensus on the post before elections.”Ruling out any new proposal for government formation, Mr. Raut reiterated that the Shiv Sena expects implementation of what was decided and agreed upon before the elections.“Why waste time on new proposals. We want a discussion on what was agreed upon earlier. No new proposal has been received or sent,” he said.On the possibility of imposition of President’s rule in the state, Mr. Raut said, “We will not be responsible for it. Those conspiring to do this are insulting the people’s mandate.”He said wherever Uddhav Thackeray and his son Aaditya Thackeray, who won the state polls from Worli seat in Mumbai, were touring to review crop losses due to unseasonal rains, the farmers and working class were looking at the party with hopes and expectations.“All are eager to have chief minister from the Shiv Sena,” he said.Mr. Raut refused to respond to a question on whether the NCP has agreed to share the chief minister’s post. “We will talk about it,” he said.The Sharad Pawar-led NCP on Tuesday said a political alternative can be worked out in the state if the Shiv Sena declared that it had snapped ties with the BJP.Sources in the NCP said their party wants Arvind Sawant, the lone Shiv Sena minister in the Union government, to resign before going ahead further with the Sena.There has been no headway in government formation after results of the state polls were declared on October 24.The BJP, which won 105 seats, and the Shiv Sena, which bagged 56 seats, are locked in a bitter tussle over sharing of the chief minister’s post and ministerial portfolios in new government, even 13 days after the Assembly poll verdict handed them enough seats to cobble up a coalition government.They won 161 seats together in the 288-member House, much above the halfway mark of 145.Besides, the opposition NCP won 54 seats while the Congress got 44 seats.last_img read more

INQUIRER SPORTS Top 7 Stories of the Year: #UPFight

first_imgMaking it at No. 5 on the list of top sports stories of 2018 are the University of the Philippines Fighting Maroons.ADVERTISEMENT Nets beat Hornets in 2OTs on Joe Harris’ late layup View comments BREAKING: Corrections officer shot dead in front of Bilibid Sports Related Videospowered by AdSparcRead Next SEA Games: Biñan football stadium stands out in preparedness, completion University of the Philippines captured the hearts of many and stole the UAAP spotlight after making its first finals appearance since 1986.After a series of losing seasons, including winless campaigns, the Fighting Maroons finally broke through in Season 81.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSUrgent reply from Philippine ‍football chiefAt the forefront of UP’s dream run were steely guard Paul Desiderio, electrifying sophomore Juan Gomez Di Liaño and Bright Akhuetie, who went on to have an MVP campaign.UP may not have won the championship after getting swept by Ateneo in the finals, but the Fighting Maroons already overachieved when they stunned No. 2 Adamson in the Final Four. But they’re far from content and next season could finally be UP’s year with Akhuetie and Di Liaño back in tow and the likes of Ricci Rivero and Kobe Paras making their debut for the Maroons.RELATED STORIESINQUIRER SPORTS Top 7 Stories of the Year: SMC sweepINQUIRER SPORTS Top 7 Stories of the Year: Manny Pacquiao back as champRELATED VIDEOADVERTISEMENT Don’t miss out on the latest news and information. TS Kammuri to enter PAR possibly a day after SEA Games opening Hotel management clarifies SEAG footballers’ kikiam breakfast issue LATEST STORIES For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. LOOK: Joyce Pring goes public with engagement to Juancho Triviño SEA Games: Biñan football stadium stands out in preparedness, completion Is Luis Manzano planning to propose to Jessy Mendiola? Private companies step in to help SEA Games hosting PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss MOST READlast_img read more

Police in standoff with armed suspect in Hillcrest home

first_img Categories: Local San Diego News FacebookTwitter May 30, 2018 Posted: May 30, 2018 KUSI Newsroom Updated: 6:05 PMcenter_img KUSI Newsroom, SAN DIEGO (KUSI) — Police Wednesday morning surrounded a residence in Hillcrest and were negotiating with a distraught man who claimed to be armed with a shotgun.Officers initially responded around 7:45 a.m. to a dwelling in the 400 block of Pennsylvania Avenue where a caller reported a possible kidnapping, San Diego police Officer Steve Bourasa said.When officers arrived, two people in the residence came out, but a third person stayed inside, where he claimed to have a shotgun and a desire to harm himself, police said.Police were unable to confirm if the man had a shotgun, but as of 9:45 a.m., he was still refusing to exit the residence, Bourasa said. Negotiators were attempting to convince him to surrender peacefully.Motorists were asked to avoid the area near Fourth, Fifth and Pennsylvania avenues, portions of which were expected to be closed until the standoff ended. Police in standoff with armed suspect in Hillcrest homelast_img read more

Online video platform Dailymotion is today exclusi

first_imgOnline video platform Dailymotion is today exclusively launching a scripted series about a music student who discovers dark government secrets hidden within songs.Three-parter The Dark Prophet comes from Evette Vargas and stars Henry Rollins, Josh Meyers and Chase Felin among others and is billed as ‘The Matrix meets 24’.Dailymotion has partnered with online filmmaker distribution network Renderyard to launch the show across all territories it operates in.Dark Prophet follows a gifted student who finds messages from a covert government agency plotting a world war hidden with the binary code of songs. After bring framed for his girlfriend’s murder, he has to go underground to prove his innocence and stop the agency.Production comes from Digital Reign Productions and Dream Hunters Studios. Writer Vargas executives produces alongside Shannon McIntosh, Carlos Arriaga, Ricardo Reyes and Ariella Levitan.“Dailymotion is designed to make it easy for leading and emerging filmmakers to realise their ambitions by reaching our global audience of 120 million viewers,” said Dailymotion’s VP, international content Marc Eychenne.“We have worked hard to develop and deliver the high quality technology platform that both does justice to the work of young artists and provides agreat viewing experience for our users. We are happy to be bringing more work from upcoming artists to our viewers through this exclusive partnership.”last_img read more

Vodafone España has teamed up with OnMobile to lau

first_imgVodafone España has teamed up with OnMobile to launch a dedicated kids app, Kids Planet, with over 3,000 episodes of content aimed at children aged three to 12.Content channels on the app include Sanrio, Planeta Junior, Highlights for Children, Lingo Kids and Motion Pictures.The app will give Vodafone customers access via a range of devices to a catalogue of games, videos, stories and songs featuring characters including Los Pitufos, La Abeja Maya, Heidi, Marco, La Granja de Zenón, Hello Kitty, Érase una vez el hombre, Pororo and Cleo.The app includes parental control features including a secure area that prevents kids from accessing other apps or navigating the open internet, different age-appropriate profiles for children, limits on the number of hours that the service can be used and the ability to track which content has been accessedThe app offers content in Spanish, English and Catalan and allows downloading for offline access. It is advertising-free.Vodafone customers can access Kids Planet on smartphones and tablets, with a one-month free trial. The service is available via Google Play, Vodafone Start and on the web, with iOS availability to follow.last_img read more

Loophole lets you tap Big Oils cash stash… Big

first_img“Loophole” lets you tap Big Oil’s cash stash…Big Oil made out like bandits when gas prices hit $4.How about using this little-known “loophole” to get some of that cash back?And not just a tiny stock dividend either — this can pay you up to three times the income most stocks or bonds pay. Even though this move has nothing to do with the stock market.Watch this video below for details. It was apparent, at least to me, that not-for-profit sellers were about in both the metals and their respective shares again yesterday.The gold price was up about twelve bucks or so just a few minutes before 9:00 a.m. in London yesterday morning…and that was the high tick of the day.  From there, the price swooned five dollars or so before almost regaining its old high shortly before 1:00 p.m. GMT…about twenty-five minutes before the Comex opened at 8:20 a.m. in New York.From that secondary high, the gold price got sold off about a percent, with the low of the day [$1,714.90 spot] coming at 9:45 a.m. Eastern time.  The subsequent rally ran into a not-for-profit seller at precisely 11:00 a.m…and from that point, the gold price got sold off about five bucks into the close of electronic trading at 5:15 p.m.The gold price closed at $1,721.90 spot…down 20 cents from Friday.  Net volume was very light at 94,000 contracts, give or take a thousand or so.In fits and starts between the Sunday night open…and its high of the day a few minutes before 9:00 a.m. in London…the silver price rose about 45 cents.  But, once again, the moment that it broke through the $34 spot price level, a not-for-profit seller showed up and sold it down about two bits.The price more or less stayed at that level until precisely 1:00 p.m. in London [twenty minutes before the Comex opened]…and then selling began anew, with the low of the day coming at 10:15 a.m. in New York.And, like gold, the subsequent rally in silver ran into a not-for-profit seller at precisely 11:00 a.m. Eastern as well.  The subsequent rally ended shortly after the Comex closed for the day…and silver traded sideways for the rest of the Monday trading session.Silver closed the Monday trading day at $33.72 spot…up the magnificent sum of 13 cents.  Net volume was a rather small 25,000 contracts.The dollar index gapped down about thirty basis points right at the open on Sunday night in New York…recovered most of that within an hour…and then rolled over…hitting its low of the day [78.62] at 8:45 a.m. in London [3:45 a.m. Eastern]…which happened about ten minutes before the high tick of the day in both metals.From that low, the dollar index steadily gained back about 40 basis points of its loses by the close of trading late in the New York afternoon…and the index closed a few basis points above the 79.00 mark…and is still heading higher as of this writing, which is 11:04 p.m. Eastern.The dollar index finished unchanged from its Friday afternoon close in New York.A cursory glance at the Kitco gold chart above shows that the gold price was rather reluctant to head south as the dollar headed north…and the last two sell offs of the day [7 and 11 a.m. Eastern time] look like the handiwork of not-for-profit sellers, as every time they stopped selling, the price rose.  Ditto for silver…and platinum.The gold stocks gapped up at the open, but one or more not-for-profit sellers used the opportunity to beat the stocks into the red by 10:15 a.m. Eastern…and the moment that the subsequent rally made back into positive territory, there was someone waiting to sell it off once again.It’s as plain as day that the gold stocks would have finished in the black if it wasn’t for this indiscriminate selling.  Sprott Asset Management’s John Embry and I [plus many others] are in full agreement on this one…that ‘da boyz’ are not only dicking with metal prices themselves, they are managing share prices as well.The HUI closed down 0.47% yesterday.The silver shares were a mixed bag yesterday…and Nick Laird’s Silver Sentiment Index actually close up 0.04%.(Click on image to enlarge)The CME’s Daily Delivery Report showed that only 10 gold contracts…but a rather large 127 silver contracts…were posted for delivery tomorrow.  In silver it was, as usual, Jefferies as the short/issuer…and the Bank of Nova Scotia and JPMorgan as the big long/stoppers…receiving 108 of those issued contracts.  UBS stopped 14 contracts.We’re about half way through February…and 585 silver contracts have already been delivered so far this month.  This goes along with the 1,600 of so that were delivered in January.  These are amazing amounts for these two months which, as I’ve said before, are not normal delivery months for silver.Both Ted Butler and myself would love to be flies on the wall over at Jefferies these days, as they’ve been the short/issuer on just about every one of these 2,200+ contracts delivered since the beginning of the year.  That’s 11 million ounces dear reader…over five days of world silver production in total…and that ain’t chopped liver.The link to yesterday’s Issuers and Stoppers Report is here.There were no reported changes in GLD yesterday…but over at SLV, authorized participants withdrew 1,360,461 troy ounces of silver.There was a small sales report from the U.S. Mint yesterday.  They sold 1,500 ounces of gold eagles…500 one-ounce 24K gold buffaloes…and 25,000 silver eagles.  The month-to-date totals aren’t worth mentioning…and the mint isn’t even close to selling a million silver eagles yet this month.Friday was pretty slow over at the Comex-approved depositories, as they didn’t receive a bar of silver…and only shipped 46,522 ounces of the stuff out the door.  The link to this little bit of activity, is here.On Friday I forgot to check the short interest in silver over at the shortsqueeze.com website.  I normally check it every day, but with the Commitment of Traders Report…and the Bank Participation Report to write about in Saturday’s column as well, it just never crossed my mind.  However, silver analyst Ted Butler didn’t forget…and this is what he had to say about what he saw…“The first big development this week is one that caught me by surprise, although perhaps I shouldn’t have been completely surprised. I’m speaking of the new report on the short position in shares of SLV, as of the close of business January 31st. Where I was girding for an increase in the short SLV position (since we climbed nearly $4 in price for the two week reporting period), instead there was a very big decline in the short position of more than 35%. The short position in SLV declined by 9.4 million shares (ounces), from 26.6 million to under 17.2 million shares. This is the biggest two-week reduction in the SLV short position in my memory…and the first I can recall when silver prices were advancing. The decline in the SLV short position brought it down almost 50% from the high-water mark of over 36 million shares in the spring of 2011. Here’s the link to SLV’s short position over at shortsqueeze.com.”“I admit to doing a double-take when I first glanced at the numbers. As I previously reported, towards the end of December, I received a very threatening letter from lawyers representing BlackRock, the sponsor of the SLV, demanding that I cease defaming their client on the shorting SLV issue. By coincidence, on the same day I received the letter, I got a call from a fellow subscriber and friend (who is a European money manager) and when I told him about the letter, he told me that it probably meant that BlackRock was taking this very seriously and would move to get the SLV short position reduced, despite the threatening tone of the letter to me. I told my friend that I thought (and hoped) that he was correct and we would see if we were correct in future short reports as they were released.”“I can’t help but feel that the most plausible explanation for the dramatic reduction in the SLV short position (especially on rising prices) is as my European friend predicted, namely, that BlackRock came to realize that the shorting of SLV was fraudulent and manipulative and they were working to eliminate it. Of course, I don’t want to be overly optimistic…and if we witness future big increases in the short position of SLV, that would indicate [that] we were back to the old fraud and manipulation in the shorting of those shares. But let’s take it one day at a time and reserve judgment on whether we go back to the bad old ways of short selling in SLV.”Before heading into the stories I have for you today, here’s the chart of the U.S. M3 money supply updated as of Friday’s close.  It’s a pretty sick looking puppy…and if this continues for any length of time, we’ll see the Fed begin QE3 pretty quick, as deflation is not on their play list.  I thank Nick Laird for sending it to me.(Click on image to enlarge)Being a typical Tuesday column, I have a lot of stories for you today.  I hope you have time to skim them all.Life isn’t about finding yourself…it’s about creating yourself. – Author UnknownIt was apparent, at least to me, that not-for-profit sellers were about in both the metals and their respective shares again yesterday, as both gold and silver…and the shares…would have had a much better time of it they hadn’t made an appearance.  There was nothing free market about Monday’s price action.But since volumes were pretty light, it wasn’t difficult to shove the metal prices around…and as I noted further up, silver was not allowed to closed about $34 spot again.In about ten days we have option expiry for the March contract…and I’m wondering whether or not JPMorgan et al will take the opportunity to lean on the metals as we head into that date.  We’ll find out soon enough I would think.Overnight, both metals declined as the dollar continued to rise…and the moment that London opened for business, both metals got sold off a bit more.  As of 5:04 a.m. Eastern time, gold is down a few dollars and silver is down about 30 cents.  The dollar index is up just a bit over 25 basis points…and appears to have topped out about an hour before London began trading.  Volume in both metals is starting to get up there…and it’s obvious that the ‘inflate, or die’ news from the Bank of Japan had no impact on the gold price, at least not for moment.  Jim Rickards is right…currency wars it is…and it’s only a matter of time before the precious metal prices begin to reflect that.That’s it for today.  I’ll see you here tomorrow. 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One Month Ago

first_imgOne Month Ago Silver34.6928.9240.25 The #1 Reason Inflation Will WinJeff Clark: I was struck at our summit by how many speakers have come to the same basic conclusions we have – that there’s really no way out of the US debt hole. That has a lot of implications, but first, in your view, how bad is it?Terry Coxon: It isn’t so bad that you should think of it as the end of the world, but there is a lot of trouble stored up, and I think “no way out” describes the situation accurately. Most of our economic trouble has been built up by government actions to solve past problems, and what they’ve done is to buy time and provide painkillers, but in doing so they’ve made the problems even worse.Jeff: Why, specifically, is there no way out?Terry: Let’s start with the Federal Reserve and the money supply. In response to the collapse of the housing bubble and most financial markets in 2008-2009, the Federal Reserve began printing like crazy. The monetary base more than doubled, and the M1 money supply at this point has risen a little over 60%. The reason we haven’t seen rapid price inflation is that people are still squirreling away dollars because they’re still very worried about the prospects for the economy. But that’ not the end of the story. The Federal Reserve will keep printing – as everyone knows by now, Mr. Bernanke has pledged allegiance to the printing press and assured the markets that the printing isn’t over and won’t be over until the economy revives.Sooner or later, the Federal Reserve will have created so much cash that many people – maybe most people – will be glutted with dollars, and buying anything will look good compared to holding on to more dollars. At that point, the urge to buy – whether it’s capital goods or consumer goods or commodities – will revive the economy, and the recession will come to an end. That will reduce the level of caution people feel to something near normal. The result will be that all of the excess money that has been created since 2008 will come pouring out. For a little while it will look like happy days are here again – the economy will seem to be booming. But then the excess cash will set off hair-curling price inflation. And that’s just the monetary side of the problem.Now look at the budget side of the federal government. They have been operating on the old Keynesian formula of deficit spending to revive a stagnant economy. What Lord Keynes perhaps never considered was that even if that prescription worked – and there is precious little evidence that it does work – there is a limiting factor over the long run. That limiting factor is the ability of the government to service debt that gets larger and larger. The US balance sheet is already at the gateway to the danger zone. When accumulated debt exceeds annual gross domestic product (think of it as annual income for the whole country), that’s where governments start to get into trouble in the capital markets.Now the budget situation – or the debt-financing situation for the US Treasury – has been made exceptionally easy by the exceptionally low interest rates that have been engineered by the exceptionally rapid growth in the money supply. When the economy starts to revive, interest rates will go up, and then the cost to the US Treasury of rolling over its now $16 trillion in debt will become a noticeable element in the overall budget. That pushes the government closer to a debt spiral, where the rise in interest rates makes it more expensive to service debt, which means the debt accumulates even faster. At that point, doubts about the ability of the government to service the debt over the long run forces another kick up in the government’s borrowing costs. It becomes a nasty and vicious feedback cycle that is similar to what is going on now in Greece and Spain. This is a predicament the US government is just whistling about. They’ve closed their eyes to the risk.So between the built up inflationary pressure that will come roaring out when the economy revives and the constantly growing US government debt, there is no solution to the economy’s problems that is politically acceptable.Jeff: Some economists think we’ll eventually grow our way out of this. We’re still the superpower of the world and still generate a lot of GDP, so can’t growth eventually pay back all this debt?Terry: In principle, such a thing is possible, but it would require political measures that are impossible. They would have to throw out most regulation of the economy, sell off an empire of unneeded real estate, stop using soldiers, ships, and planes as pieces in a “big boys’ really big chess set,” and starting saying “no” to the many people – both rich and poor – who now live off the government.Jeff: Why aren’t more economists expressing concern or even outrage over the predicament we’re in? It seems so obvious.Terry: If you studied economics when you went to school, the economics department probably was within a short walk of the science building, where they studied physics and chemistry. That leaves people with the false impression that economics is a hard science like physics or chemistry, where there are clear, proven principles anyone can test and everyone can agree on. In fact, economics today is about where medicine was in the 17th century, when people were debating whether the blood circulates through the body or just sits there. That was the level of knowledge by the best minds of the day, and it is the level of understanding by economists today. So you shouldn’t be surprised that most economists are sure that most other economists are wrong.Jeff: So what happens – high inflation? There are some strong deflationary signals in the economy right now.Terry: Even if there are episodes of deflation, they will just inspire even faster money printing. In the contest between inflation and deflation, inflation always gets another turn until it wins.Jeff: Good point. Is inflation imminent? The CPI is still pretty low.Terry: Well, it’s never going to be imminent in the sense that today it’s not happening and next week it is happening. It’s more like a river rising. And when you see the economy start to revive, the rate of price inflation will start rising noticeably in a year or year and a half.Jeff: This has obvious investment implications.Terry: Yes. You and your family should think about how to protect yourselves, and the formula sorts out to something very simple. One, you need some gold in your financial life, and two, you don’t need any bonds in your financial life.Jeff: Yes. Anything else?Terry: Well, those are the most obvious – gold yes, bonds no. You should also keep a good holding of cash in your investment portfolio, because there probably will be one or more replays of what we saw in 2008 and 2009. And when that happens, you will be glad you have cash because you can take advantage of the bargains.Conventional stocks are a bit of a quandary. On the one hand, the equity market welcomed the restarting of the printing press. On the other hand, the equity markets, as they go up, are diverging from economic reality. So I suggest thinking of a portfolio of conventional stocks as a machine that sits in your office and churns out ten-dollar bills, but eventually is going to blow up. If you want to take the risk that you’ll know when to get out, well, at the end of the day, if you’re right and you get out in time, you will be glad that you invested in conventional stocks. If you are thinking about a portfolio that you can just put away and forget about, then conventional stocks should not be part of it.Jeff: Bernanke said the $40 billion of bond-buying every month is open ended, implying it could last awhile. Any sense for how long it goes on before the economy revives?Terry: Open-ended is an extraordinary thing to announce. The fact isn’t surprising, but I am surprised they would ‘fess up to it.The picture I have is someone sitting next to a pile of damp firewood, lighting matches and just throwing them on. Eventually those matches are going to dry out the firewood, and then you will get a big blaze; and that’s what the Federal Reserve is doing to the economy right now. The difficulty is that if you’re in charge of printing all the new dollars, you won’t know that you’ve printed enough until you’ve printed way too much.Jeff: That implies gold and silver prices have a long way to go yet.Terry: Yes, I certainly believe so.Jeff: What kind of price levels do you expect?Terry: The only reasonable thing that I can say is, a lot higher. The reason that it doesn’t do much good to put a number on it is that we don’t know how long rapid rates of inflation will run.Jeff: What about gold stocks? If you’re lukewarm on the stock market, can gold stocks still do well?Terry: The basic answer is, if you want to own stocks right now, don’t own red stocks, don’t own blue stocks, own gold stocks.Jeff: Silver is considered a monetary metal, too, but is there a scenario under which gold does well but silver does poorly?Terry: Yes: runaway inflation and a very sick economy that is not consuming a lot of silver. That could leave silver behind, but it would have to be a very ugly economic situation.Jeff: But wouldn’t the Fed just print more money and make silver as attractive as gold?Terry: Not necessarily. The demand for gold is financial demand, period. Silver is a different story altogether. It is partly financial demand and partly industrial consumption.Jeff: What odds do you give for something like that happening?Terry: I don’t expect that to happen. If it happens at all, it’s years away.Jeff: So the bottom line to all this is, make sure you own enough gold.Terry: That’s exactly right.Gold and Silver HEADLINESMining Investment to Grow Ever More Complex and Costly, Industry Leaders Fear (Mineweb)Baker & McKenzie surveyed more than 300 senior mining industry leaders across six mining jurisdictions – Australia, Brazil, Canada, China, Indonesia, and South Africa. The key themes in the study were the complexity of the legal and regulatory environment, political stability, resource nationalism, access to infrastructure, and skilled labor. A common thought expressed by the majority of the respondents across these jurisdictions is that “investing in mining is becoming more difficult and less certain,” and they believe that mining sector investment will continue to be more complicated.This research confirms what other mining industry surveys report. Resource nationalism, named the #1 threat for mining, is expected by the majority of respondents (78%) to increase over the next 20 years. That’s why it is so important to understand investor friendliness of any given jurisdiction. And navigating the political landscapes is exactly what we do in International Speculator and BIG GOLD.Silver ETF Holdings Nearing Record Levels (Silver Institute)The Silver Institute reports that silver ETF holdings have totaled more than 608 million ounces with a value of US$20.5 billion through September 15. Investors have added more than 32 million ounces to their silver ETF accounts so far this year. Investor demand was one of the most important factors cited in silver’s recent price rise.“Investors and analysts are bullish on expectations that additional central banks will do more to attempt to stimulate economies in order to increase consumption and spur employment, leading to even greater investor attention on the 4,000 year allure of silver as a safe haven and a store of value,” said Michael DiRienzo, Executive Director of the Silver Institute.We agree that investor interest for silver will drive the price higher. TSX (Toronto Stock Exchange)12,383.6012,116.9211,955.01 Gold1,784.501,639.501,793.00 Copper3.773.463.75 Oil91.8796.6885.92 Silver Stocks (SIL)25.2620.5626.29center_img TSX Venture1,345.721,239.321,703.78 One Year Ago Rock & Stock StatsLast Dear Reader,Economist Terry Coxon and BIG GOLD Editor Jeff Clark had some interesting discussions during the recent Casey Research Summit on Navigating the Politicized Economy. They noticed a near-consensus among the speakers that there’s no way out for the over-indebted US government – or the Eurozone for that matter – which has consequences for all participants in the global economy. Below, you can read why Terry (and others) are convinced there’s no way out, why he’s convinced the problem will end in inflation, and what the investment implications are for gold and silver.How do we profit from that? Even as you receive today’s Daily Dispatch, Jeff and I will be flying down to Mexico to look at a silver mine one of our companies recently acquired. Due diligence: pick right and sit tight. That’s how we do it – and you can too.If you want to learn more about the Casey Research process or pick our brains in some other way, please consider joining Doug Casey, our Chief Energy Investment Strategist Marin Katusa, and myself next month in New Orleans. We’ll all be speaking at the New Orleans 2012 Investment Conference, which will be held October 24-27. You won’t want to miss Doug’s debate against James Carville and Charles Krauthammer – it’s sure to be a memorable event. The markets are getting really interesting, so you’ll be sure to learn a lot.Sincerely,Louis JamesSenior Metals Investment StrategistCasey Research Gold Producers (GDX)54.8146.3864.28 Gold Junior Stocks (GDXJ)25.4621.4635.10last_img read more

In This Issue   Gold Commodities plunge even f

first_imgIn This Issue.*  Gold & Commodities plunge even further. *  Currencies join in with stocks and commodities. *  RBA talks about low inflation. *  U.S. data cupboard returns.And, Now, Today’s Pfennig For Your Thoughts!Will The Healing Last?Good day.  And a Tom Terrific Tuesday to you! What a horrific scene in Boston at the Boston Marathon Finish Line yesterday. On Patriot’s Day in Boston, someone or some group planted bombs near the finish line and set them off yesterday as thousands of participants attempted to finish and spectators watched. Here’s what I know at this point: The White House says the explosion will be handled as an act of terror. Three people have lost their lives and over 100 are injured with at least 8 in a critical condition. So far, no group has come forward to take responsibility for the attack.So, it’s with sadness that I begin today’s letter. I have to think that we as a country have been pretty lucky that we don’t experience this type of stuff like they do in the U.K. So, let’s keep the people in Boston in our thoughts, and move on to the markets.Well. Yesterday, I told you about how Gold was down $80 in the morning. Then as the morning went along, it seemed some healing was happening and Gold began to bounce, but that bounce had little to the ounce and soon Gold was back on the slippery slope as I left the office for the day. The Gold to stocks trade, didn’t carry through as even U.S. stocks got taken to the woodshed yesterday, It was all about buying Treasuries, as the 10-year Treasury yield fell to 1.67% (remember for bonds yield and price move in opposite directions, so as the yield falls, the price goes up)There are more thoughts out on the street about why Gold is falling like a rock from the sky, but I think I’ll stick with my theory that the “boys” on Wall Street are behind all this, and probably with the blessings, wink and nod from the Gov’t. they saw an opening to drive the price down, and they did. And will continue to do so, until they feel that Elvis has left the building. (masses have panicked and sold). That’s my story and I’m sticking to it!Long time readers know that I have quoted my friend, Bill Bonner, many times over the years, and so in this time of crazy theories about what’s going on, I turn to Bill to see what he thinks. By the way, one of the theories out there, plays well with my conspiracy tendencies.  It goes like this. The Big Boys in concert with the U.S. Gov’t are driving the price of Gold lower, so that the U.S. can buy it cheaper, and therefore have the Gold to deliver to Germany.  Hey. I’ve heard of crazier things that turned out to be fact!  OK.. any way. here’s a snippet of what Bill Bonner had to say about the Gold selling that the NY Times reported on yesterday.NY Times- “So Wall Street is growing increasingly bearish on gold, and investment that banks and others had deftly marketed to the masses only a few years ago.”Bill Bonner’s response – “Ha-ha. Do you remember Wall Street deftly marketing gold to the masses a few years ago? Show us the ads! Give us the broker’s phone logs! Prove it! The fact is, the masses never got anywhere near gold. Not even close. Most people have never seen a gold coin.. Which is why we’re nowhere near a top. Wall Street never marketed gold deftly.. or any other way. Not even in its usual greedy, heavy-handed fashion. And the masses never bought it. Just the opposite. Yes, dear reader, we hope Goldman and SocGen are right. We’d like to see gold crash down around $1,300… or lower. First, because this would mark a real correction in the bull market. It’s been going on for 12 years without a serious correction. Not a healthy situation. We’d like to get the correction out of the way… shaking out the Johnnies-come-lately and the two-bit speculators. Then, the final stage in the bull market could begin.”I usually get the ship righted after reading Bill’s thoughts. Any way.This selling has been a paper event. Yes, an ETF liquidation, and that’s what leads me to believe that when the paper selling is over, the physical demand which has remained strong all during the 20% drop in Gold’s price since reaching a high of $1,921 a couple of years ago, will take over, and a slow grinding recovery will take place. When will that happen? I don’t know. Better asked of the “boys” who are doing the paper selling.OK. So, yesterday, the Commodities and Commodity Currencies were the assets on the chopping blocks, the rest of the currencies held their own. Well, the selling of the Commodities and Commodity Currencies became too much to bear, and eventually the selling spilled over to the rest of the currencies. The thing I found to be surprising though was the selloff in U.S. stocks yesterday. That was not something I expected during this sell Gold and risk assets timetable.But that was yesterday. But it’s not the end of the world, just a slight change of plans. This morning, I’m seeing some healing once again, with Gold  up $35, the euro back to 1.31, and the Aussie dollar (A$) up 1/2-cent.  Yesterday, I said something about the A$ that I was shocked that thousands of readers didn’t throw right back in my face. I said that the A$ was down $1. YIKES! That should have been 1-cent!  Thanks for not spanking me with that faux-pas!The A$ move higher is curious, given the Reserve Bank of Australia (RBA) meeting minutes that printed last night, in which the RBA talked about how the lower inflation gives them room to cut rates, and then made a statement about how the A$ had remained “high”.  The markets like to get all lathered up over these meeting minutes that Central Banks print a month after the meeting took place. I find that laughable, but then, it’s the markets, it’s not as if these guys are rocket scientists! But that’s the norm in the markets, Shoot Rudy, they do the same thing with backwards looking data!It’s been some time since I talked about the German Chancellor, Angela Merkel. And that’s probably a good thing! But this morning in Germany, the Chancellor told a crowd something that I think she should be commended for. Let’s listen in. “We know that there will have to be victims from this austerity in many countries. But, I believe that in the long term we’ll have to have a growth strategy without always having to pile on debt. The piling up of debt is often made into a type of obligation to serve the principle of growth. All of that is false. It’s not sustainable in the long term.”I think that Ms Merkel had U.S. Treasury Sec Lew in mind with those comments, as it was just last week that Mr. Lew, told the Eurozone Finance Chiefs that they needed to shift toward generating economic expansion like the U.S. has done through monetary measures.  You know, we have no idea where all these monetary measures are going to take us, but I would pin my colors to the mast that calls for mass problems, and not the mast that says we’ll be just fine from all these stimulus measures.The Petrol Currencies that include: Norway, Brazil, Canada, Mexico and even the U.K. not only had to deal with the selling in the Commodity Currencies, but also the selling and the subsequent drop in price of Oil.  The WTI Oil price which is the one I quote in the currency roundup each day is below $90 (at $88) and the Brent Oil price has fallen below $100. Still a long way from the $40 oil I was promised 2 years ago.Another thing weighing on the markets is the renewed war rhetoric from N. Korea. News of N. Korea’s warning to S. Korea that a “strike will start without any notice” is not doing the risk asset any favors this morning.  But, a recovery in the risk assets, like I told you about above is going on, so maybe the markets are beginning to think of N. Korea’s warnings like the boy who cried wolf. probably not a good idea, but it is what it is.And for those of you keeping score at home, the Chinese have added another country to their roster of countries that they trade with and exchange each other’s currencies, leaving out U.S. dollars from the terms of trade. This time it’s France.  OK, the agreement hasn’t actually been signed yet, but like the other countries that were added to China’s roster, once the verbal announcement has been made, the actually signing is just a formality.  France is actually getting a leg up on the competition by doing this.  You see, Paris would love to be the offshore renminbi / yuan trading hub in Europe, beating out London. So, getting into bed with the Chinese now, might serve them better when the time comes.As I told you yesterday, the U.S. Data Cupboard has some items to yield to us today. Two of my faves. Industrial Production and Capacity Utilization, Housing Starts, and Building Permits will all print their results for March today. We’ll also see the stupid CPI reports and you can bet your sweet bippie that some Gov’t official will make certain to point out that inflation in the U.S. is still not a problem.  I do expect to see some more rot on the vine exposed, in the Industrial Production and Capacity Utilization reports. And once again, I’ll do my best Alfred E. Newman, and say, recovery? What recovery?Then There Was This. Caroline Baum, a columnist for Bloomberg News, has always been a fave read of mine.  Yesterday, she submitted this article on Japan, and the U.S. Treasury. It’s a good read, so here’s a snippet.“With a new president and central bank governor in place, Japan has finally decided to get serious. Earlier this year, Prime Minister Shinzo Abe announced a “monetary regime change” including a 2 percent inflation target. On April 4, following its regular meeting, the Bank of Japan made its “quantitative and qualitative monetary easing” official.The BOJ will double the monetary base by purchasing about 7.5 trillion yen of Japanese government bonds per month. It plans to extend the average maturity of its portfolio from three to seven years. And it will continue such actions until it achieves its inflation target.In other words, the BOJ is doing exactly what the Federal Reserve is doing.And for this it gets a warning from the U.S. Treasury “to refrain from competitive devaluation and targeting its exchange rate for competitive purposes”?Chuck again. yes. this a case of the kettle calling the pot black. I just don’t see how the U.S. can do the “do as we say, not as we do” thing, and then beat on Japan for doing what they said to do.To recap. The selling continued all through the day yesterday in Gold and then the other currencies joined in.  But that was yesterday, and today, we’re seeing some healing in the price of Gold and the currencies. The gold selloff has been an ETF, paper event, folks. not physical gold. I keep saying that.Currencies today 4/16/13. American Style: A$ $1.0374, kiwi .8490, C$ .9790, euro 1.3120, sterling 1.5310, Swiss $1.0790, . European Style: rand 9.1335, krone 5.7335, SEK 6.3875, forint 224.85, zloty 3.1365, koruna 19.7105, RUB 31.34, yen 97.85, sing 1.2355, HKD 7.7620, INR 54.14, China 6.2408, pesos 12.17, BRL 2.005, Dollar Index 82.15, Oil $88.22, 10-year 1.71%, Silver $23.52, and Gold $1,386.39That’s it for today. With all the news stations going 24/7 on the Bombing in Boston last night, I was taken back, in my mind, to 2001. The strange chills returned with each news update. At least I was able to watch my Cardinals and get my mind off that stuff for a couple of hours.  I made my presentation on our business yesterday, I guess it went OK, nobody threw darts at me! I have one more day of “stuff” to do and write in my office today, and then back out to the trade desk! So, did you get your taxes filed? I actually came out about even this year, which is always a good thing for me, but somehow, I paid a higher tax rate than the President. I’ll stop there, before I say something that gets me in trouble!  I hope you have a Tom Terrific Tuesday , and keep those folks in Boston in your thoughts.Chuck Butler President EverBank World Markets 1-800-926-4922 1-314-647-3837last_img read more

North Carolinas attorney general is joining a law

first_imgNorth Carolina’s attorney general is joining a lawsuit against a health data company that allegedly lost private patient data to hackers.Attorney General Josh Stein announced this week he’s joining 11 other states in suing Indiana-based Medical Informatics Engineering for violating the Health Insurance Portability and Accountability Act, also known as HIPAA.According to Stein, in May 2015, hackers infiltrated an app called WebChart that’s run by MIE. They then stole the private information of nearly 4 million people, including tens of thousands of North Carolinians.The information potentially included everything from names, to Social Security numbers, to disabilities and medical conditions.Stein says the state is joining the suit in an effort to push companies to do a better job of protecting private information.This is the first time that multiple attorneys general have come together to pursue a HIPAA-related data breach case.last_img read more

TechBytes with Vinayak Nair VP Research Ops and Custom Analytics at Verto

first_img Tell us about your role and the team/technology you handle at Verto Analytics.I am our Head of Custom Research, responsible for delivering high-quality data and insights to our clients, some of which like Google are among the biggest technology companies in the world. I am responsible for using our data assets, methodology, panels, to create insights and research to answer our customers’ business questions.Why are B2B marketing teams steadily moving toward Applied Data Science for Sales and Marketing initiatives?Traditionally this used to be very F2F-driven, all about relationships and real people talking to each other. However, in today’s digital world an increasing share of B2B decisions and investments are done online which leads to the marketing and sales focus to also pivot to micro-targeting using online clickstream data to understand who is a possible consumer thereby making marketing spend more efficient and targeted. In order to accomplish this, Data Science and Engineering are key to synthesize that information from large volumes of data. For example what actions/pathing indicate that someone is in-market for a B2B product?What is the current definition of Mobile Customer Experience? How is it different from desktop CX?We define mobile customer experience to be the result of the user’s activities and engagement, interaction and its smoothness, with mobile devices and digital services through these devices, as opposed to the use of similar assets but on the big screen computer-type devices. Increasingly there is a shift of online purchasing and decision making to Mobile devices as User Experiences on these devices are becoming more efficient and seamless.Tell us more about the changing nature of Digital Experiences and how it impacts experience delivered through the Mobile Marketing campaigns?Today’s digital campaigns, and definitely the capabilities brought on by mobile, are enormous. The biggest differences are in the fact that one can reach the individual consumer, on a one-by-one basis (mobile devices are not shared), all the time and everywhere, at the point of context and user attention – using for example locations and other such contextual variables based on online clickstream data are integrated parts of the campaign delivery and targeting.How have the customer’s expectations evolved in the last 2-3 years when it comes to interacting with brands over Mobile devices? Do you have some specific data related to this evolution of customer preference?The expectations of customers have changed significantly. Back in the day, it was thought that mobiles are yet another screen or device to use in targeting people. Today’s brands expect more native and sophisticated use of the unique characteristics of mobile devices (see above), and increasingly want to make sure the role of mobile advertising in the overall mix is well thought and optimized.We have data to quantify this as well given the longitudinal nature of the panel and can compare if panelists are more/less active on their Mobile devices compared to a year or more ago.Tell us about the three major takeaways from your recent report on Mobile data. How can marketing team better leverage your report findings to understand consumer behavior?The report’s major takeways are less actionable than they are predictive of several key possible changes in mobile.Consumer Attention at Unlock Will Become “a Thing”:  The report begins to peel back and inspect the first moments of consumer attention on mobile.  The findings certainly support that those first moments done right positively impact companies, influencing engagement, content consumption and revenues.  So we think that this topic will get greater attention from brands, publishers, ad tech, carriers, smartphone OEMs and more.Research Must Continue to Evolve: The findings create as many questions as they answer.  Given the potential impact on so many mobile stakeholders, we certainly expect this to be the first, but not the last, set of insights on this topic.Smartphones Will Change: What is certainly clear, is that our findings support that our “smart”phones could, would and ultimately will be smarter when they do a better job of more frictionlessly delivering the content and apps a consumer may want to use.  There are many ways this might be done.  Many will be tried, and Verto looks forward to trying to understand how well they work.How do you see Big Data and Customer Intelligence coming together to solve identity-related issues?We believe the fact that we have opt-in based datasets and services, and aggregators and intermediaries like Liveramp which make it possible to do data deals and overlaps, with anonymous matching, respecting all the local laws.Tell us about the various steps of the AI-powered Mobile Marketing journeys. How do consumers from different global locations interact with advertisements and marketing campaigns?There are lots of differences how different cultures react to contextual and more intelligent advertising. For example, Europeans tend to be more conservative with privacy, while Asians and Americans are more receptive to intelligent and contextual targeting.What are the different scenarios AI could be applied to in Marketing, Sales and Customer Service?There are many. We see that continuous optimization and on-the-fly adjustment of campaign creatives and targeting is one area where more intelligent use of return-path data and feedback loops could pose a big opportunity for AI (no static campaigns), the big opportunity is to provide real-time support via bots, which we have seen increasing in use lately.How do you build analytics around Cloud and Enterprise Mobility platforms?We are very customer-driven, so we have work flows and teams who understand and talk with customers about their needs, and we have our HQ-driven development tracks in which they implement these features into our cloud-based platform – productizing the solutions so that they are available to a high number of customers.Tell us about your customer experience products. How can MarTech customers benefit from your AI/ML products at Verto Analytics?Our single source approach (telemetry data on both PC and Mobile for the same user and ability to survey those users) enables us to get in-depth information into the consumer mindset and actions.We start with business questions, and using our methodology my team and I would propose customized solutions using both telemetry and attitudinal data to address our clients’ business problems.What is the current state of machine learning and AI for digital transformation?There appears to be a lot of hype but it’s unclear how effective the results are. Technologies and algorithms are there, but we still need to make sure the data that goes as an input is of high quality, and there is transparency and better ROI measurement especially on the ad targeting/segmentation front.How much of this state is influenced by the maturity of Data Science and Machine Learning algorithms?The algorithms and tools themselves are mature however as mentioned above the output/quality is dependent on what goes in. For example, a lot of players claim to be able to do advanced targeting using look alike modelling but is the input of the best quality? Is the output being effectively measured? Theses are questions business leaders need to consider beyond the maturity of Data Science Tools and algorithms.What are the major pain points for Data Analysts and Engineers in building/ scaling Analytics for relevant customer experience?It is always the extent of customization. Companies like us are interested in solving problems, but for us to do our work well and maximize the value-added, we need to be able to map similar problems across many customers so that we can scale our solutions more effectively.How do you work with AI/ Machine Learning at Verto Analytics?We have people with strong skillsets in this area, and apply machine learning in projects and use cases whenever it makes sense – not because it is a “cool thing to do”. For example, segmentation and clustering similar users is a common use case. About Verto Analytics About VinayakAbout Verto AnalyticsAbout Vinayak Vinayak Nair is the VP of Custom Analytics at Verto Analytics and currently works with Media, Tech, and Market Research companies to help synthesize digital consumer behavior utilizing a proprietary single-source, multi-platform panel. Prior to joining Verto Analytics, he was the Director of Analytics at comScore where he helped build and launch Audience Measurement products. TechBytes with Vinayak Nair, VP Research Ops and Custom Analytics at Verto Analytics Sudipto GhoshMay 29, 2019, 2:30 pmMay 29, 2019 Verto Analytics is a media measurement company that offers a holistic view of the consumer—their behavior along with demographics, lifestyles, attitudes, and interests.Verto owns and operates single-source, passively metered consumer panels in select markets that gives it the power to measure behavioral changes over time across all media—second by second. Brands, publishers, and researchers can benchmark against competitors and the market, fill in the gaps in the consumer journey, and identify ways to increase engagement and loyalty, with Verto’s services. B2Bclickstream datadata analyticsData and Insightsdata scienceTechBytesVerto AnalyticsVinayak Nair Previous ArticleOpenText Named a Customer Communications Management Leader in 2019 Aspire CCM LeaderboardNext ArticleThe Secret Life of an Events Optimiserlast_img read more

Why Mosquitoes prefer some people over others Genetic discovery

first_img Source: https://www.nature.com/articles/s41586-018-0692-z Aedes aegypti mosquito on human skin. Image Credit: khlungcenter / Shutterstock By Dr. Ananya Mandal, MDNov 25 2018A new study has tried to assess the genetic variants among mosquitoes that make them more susceptible to spreading deadly viral diseases such as dengue, yellow fever, Zika and chikungunya and more resistant to insecticides that are used to kill them.The study titled, ‘Improved reference genome of Aedes aegypti informs arbovirus vector control’, by researchers from seven countries, including Australia’s QIMR Berghofer Medical Research Institute, has mapped the genetic make-up of these insects which could be ground breaking in vector control.  The team was looking at the genomes of Aedes aegypti mosquitoes that carry viruses like Zika and dengue. They noted that some newly discovered genes could make them resistant to insecticides.Modification of these resistant genes may help stop the mosquitoes from spreading disease, the researchers hope. Dr. Gordana Rasic, one of the researchers said, “One of the key things that we want to achieve is to modify these mosquitoes in a way that will help control them.”center_img They looked at “physical and cytogenetic maps of the mosquitoes to see how these mosquitoes differed in their preference for human hosts for biting as well as how it alters their egg laying sites. They noted that there is a specific locus called the M locus on the mosquito genome where there is a variation in the glutathione S-transferase genes or the GST gene that is important for resistance to insecticides.Related StoriesDoes genetic testing affect psychosocial health?Gene modulation goes wireless hacking the “boss gene”Study: Causes of anorexia are likely metabolic and psychologicalThese GST genes are actually responsible for coding for proteins that detoxify and excrete the insecticides that are used to kill the mosquitoes. When modified these GST genes help the mosquitoes develop a resistance to the insecticides used against them and this makes the chemical ineffective against the pests.A look at these genes of the AaegL5 genome would help interventional strategies for vector control in controlling mosquitoes that carry the dengue virus and the Zika virus.The authors write, “high-quality genome assembly and annotation described here will enable major advances in mosquito biology.”The team also found variants of “chemosensory ionotropic receptors” among the mosquitoes. These connect the attraction of the mosquitoes to certain smells and tastes present on human skin that make them more prone to mosquito bites.The authors state in their work that this could provide clues to developing “novel mosquito repellents. ‘Sterile Insect Technique’ and ‘Incompatible Insect Technique’” that could help reduce mosquito populations. Genetic modification of the male mosquitoes could help alter the genes of the progeny is ways so that they fail to transmit the infection.The authors sign off that better understanding of the genetics of mosquitoes could “facilitate genetic control of mosquitoes that infect many hundreds of millions of people with arboviruses every year.”Mosquito bites are known to spread several life-threatening diseases including malaria, dengue, chikungunya, zika etc.Zika alone affects around 86 countries and regions around the world and can affect pregnant mothers and severely harm the unborn babies.Dengue too is a viral infection carried by mosquitoes that causes deadly hemorrhagic fever or fever along with very low platelet counts that can cause spontaneous bleeding.Malaria is a parasitic infection that still manages to kill hundreds of thousands around the world.last_img read more

Increased stress hormones accelerate breast cancer metastasis

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 14 2019It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones. In addition, they found that synthetic derivatives of stress hormones, which are frequently used as anti-inflammatory in cancer therapy, decrease the efficacy of chemotherapy. These results come from patient-derived models of breast cancer in mice and may have implications for the treatment of patients with breast cancer, as the researchers report in the scientific journal Nature.One major obstacle in the treatment of metastatic breast cancer is the phenomenon of tumor heterogeneity. As the disease progresses, the tumor becomes more diverse, and the difference between the cancer cells may lead to inadequate treatment.Because the underlying mechanisms of this phenomenon remain unclear, the research group of Prof. Mohamed Bentires-Alj from the Department of Biomedicine at the University of Basel and University Hospital of Basel has been studying the cells of a highly metastatic form of cancer known as triple-negative breast cancer. This cancer type is resistant to standard therapies leaving patients with fewer treatment options.Stress accelerates metastasisTo explore the heterogeneity between tumors and metastases, the researchers profiled the activity of genes in a mouse model of breast cancer. They found that metastases have increased activity of glucocorticoid receptors (GR) which mediate the effects of stress hormones such as cortisol.Concentrations of the stress hormones cortisol and corticosterone were higher in mice with metastases that in those with no metastases. The scientists show that increased levels of these stress hormones activate the GR, which cause increased colonization and heterogeneity of the cancer cells – and ultimately, shortened survival.Related StoriesCancer killing capability of lesser-known immune cells identifiedUsing machine learning algorithm to accurately diagnose breast cancerLiving with advanced breast cancerReduced efficacy of chemotherapyGR also mediates the effects of synthetic derivatives of cortisol such as dexamethasone which is used widely to treat the side effects of chemotherapy. The research group shows that in mice with metastatic cells the efficacy of the chemotherapy drug paclitaxel was decreased when administered in combination with dexamethasone.These findings suggest that caution should be taken when prescribing glucocorticoid hormones to patients with breast cancer. The study also suggests that GR inhibition may be beneficial for patients and could lead to the development of new therapies to combat breast cancer metastasis.”Tumor heterogeneity is a serious hurdle for therapy. These findings highlight the importance of stress management in patients – and especially those with triple-negative breast cancer,” states Prof. Bentires-Alj. “Moderate exercise and relaxation techniques have been shown to correlate with enhanced quality of life and greater survival in patients.”Basel Breast ConsortiumThe Basel Breast Consortium was initiated in 2014 by Prof. Mohamed Bentires-Alj and Prof. Walter Paul Weber, Chief Physician Department of Breast Surgery at the University Hospital Basel. It has more than 160 researchers and clinicians from academia and industry as well as patient advocates, committed to promoting research and translating basic science into leading-edge breast cancer clinical studies.Source: https://www.unibas.ch/en/News-Events/News/Uni-Research/Stress-hormones-promote-breast-cancer-metastasis.htmllast_img read more

RollsRoyce pulls out of race to power future Boeing plane

first_imgRolls-Royce no longer wishes to be a candidate to make the engine for a new midsize passenger jet proposed by US planemaker Boeing, the troubled British group said Thursday. Rolls-Royce flies into loss on Trent engine trouble Citation: Rolls-Royce pulls out of race to power future Boeing plane (2019, February 28) retrieved 17 July 2019 from https://phys.org/news/2019-02-rolls-royce-power-future-boeing-plane.html Rolls-Royce posted a net loss last year as its Trent engines were hit by costly repairs Explore furthercenter_img © 2019 AFP Rolls gave the update alongside news that it had dived into a net loss last year as its Trent engines were hit by costly repairs and a decision by Boeing’s European rival Airbus to stop making the A380 jumbo.Rolls posted a loss after tax of £2.4 billion ($3.2 billion, 2.8 billion euros) for 2018 after a net profit of nearly £3.4 billion a year earlier, as the group also decided to axe thousands of jobs as part of vast restructuring at the group.”Rolls-Royce has decided to withdraw from the current competition to power Boeing’s proposed middle of the market—or New Midsize Airplane (NMA)—platform,” the British group said in a statement.”While we believe the platform complements Boeing’s existing product range, we are unable to commit to the proposed timetable to ensure we have a sufficiently mature product which supports Boeing’s ambition for the aircraft and satisfies our own internal requirements for technical maturity at entry into service,” it added.Chicago-based Boeing is looking at building an NMA, or single-aisle commercial jet for long-haul journeys, to fill a gap in the market—but concrete plans have yet to be announced.Rolls on Thursday said that costs linked to problems with its Trent 1000 engine that powers the Boeing Dreamliner were a higher-than-expected £790 million in 2018.The Trent 1000 has seen some parts wear quicker than expected, forcing Rolls to carry out expensive repairs.The UK engineering giant added that last year’s earnings were hit additionally by a charge of £186 million “following Airbus’ decision to close the A380 production line”.Rolls in 2018 also began axing 4,600 mainly British management roles to slash costs.The company based in the city of Derby, central England, is restructuring through to next year.Also in 2018, Rolls sold its loss-making commercial marine business to Norwegian industrial giant Kongsberg.The divestment enables the UK group to focus on its three core businesses, which comprise civil aerospace, defence and power systems. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Fantastically Preserved Viking Boat Grave and Skeletons Unearthed in Sweden

first_img Photos: 10th-Century Viking Tomb Unearthed in Denmark Fierce Fighters: 7 Secrets of Viking Seamen Archaeologists recently unearthed two Viking burial boats in Uppsala, Sweden — one of which was exceptionally preserved and held the remains of a dog, a man and a horse. The Vikings sent a handful of their powerful elites to the afterlife in boats laden with sacrificed animals, weapons and treasure; the funeral practice dates back to the Iron Age (A.D. 550 to 800) but was used throughout the Viking age (A.D. 800 to 1050), according to a statement. These richly appointed graves have been discovered across Scandinavia. For example, archaeologists had previously found one such burial boat in Norway that had evidence of human remains and one in western Scotland that contained a slew of burial items such as an ax, a shield boss, a ringed pin, a hammer and tongs. The elites who were given such elaborate send-offs were also often buried with animals, such as stallions.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65892-viking-burial-boats-discovered-sweden.html?jwsource=cl已复制直播00:0000:3500:35  These burial boats were typically built with overlapping wooden planks (called “clinker built”) and had symmetrical ends, a true keel and overlapping planks joined together, said Johan Anund, the regional manager for The Archaeologists, an archeological organization working with the National Historical Museums in Sweden. Archaeologists have also found other, simpler boat structures, such as logboats, which are like a dugout wide canoe, Anand told Live Science in an email. [Photos: A Man, a Horse and a Dog Found in Viking Boat Burials] The remains of the dog and the horse were nestled in the bow of the well-preserved boat, while the remains of the man were found in the stern. “We don’t know much” about the man yet, Anund said. But analysis of the skeleton will reveal how old he was, how tall he was and if he had any injuries or diseases. Anund’s group may even be able to figure out where the man grew up and where he lived for most of his life, Anund said. As for the animals buried with him, they could have been sacrificed to help the dead person on the “other side” but could also be there to show the man’s status and rank, Anund said. It’s common to find horses and dogs in such burials, but also big birds like falcons. Archaeologists also found other items on the boat such as a sword, spear, shield, an ornate comb, and leftover wood and iron nails that were likely used in its construction. The other boat was badly damaged, probably because a 16th-century medieval cellar was built right on top of it, according to the statement. Some human and animal bones were still preserved on the damaged ship, but they seem to have been moved around, making it difficult for archaeologists to say much about them, Anund said. Archaeologists discovered the ships, the well and the cellar after a plot of land outside Uppsala was marked off to become a new building for the vicarage of Gamla Uppsala parish. They excavated the boats last month and some of the finds will go on display at Gamla Uppsala museum and the Swedish History Museum in Stockholm. Live Science Editor-in-Chief Jeanna Bryner contributed to this story. Photos: Vikings Accessorized with Tiny Metal Dragons Editor’s Note: This article was updated to correct the fact that “clinker” boats meant the boats were made of overlapping wooden planks. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoairdogusa.comThe World’s Best Washable Air Purifierairdogusa.comUndoComparisons.orgCalifornia Drivers With No Tickets In 3 Years Must Read ThisComparisons.orglast_img read more

Let there be no doubt No act of terror will go unpunished

first_img Press Trust of India New DelhiJuly 13, 2019UPDATED: July 13, 2019 14:48 IST Army chief General Bipin Rawat was speaking at an event on 20 Years after Kargil Conflict. (Photo:Pankaj Nangia/India Today)HIGHLIGHTSAny misadventure by Pakistan Army will be repelled with punitive response: Army chiefArmy chief says armed forces stand resolute and ready to defend territorial integrityRise of non-state actors and readiness to use terror and other irregular methods of fighting have become a new norm: Army chiefAny misadventure by Pakistan Army will be repelled with punitive response and no act of terror will go unpunished, Army chief General Bipin Rawat said Saturday.Speaking at an event on ’20 Years after Kargil Conflict’, General Bipin Rawat said Pakistan Army, time and again, resorts to misadventure, either through state-sponsored terrorism or intrusions in India.”The Indian armed forces stand resolute and ready to defend our territorial integrity. Let there be no doubt that misadventures will be repelled with a punitive response,” he said.The rise of non-state actors and the readiness to use terror and other irregular methods of fighting have become a new norm, he said.Addition of cyber and space domain has changed the battlefield scenario, the Army chief noted.Rawat also asserted that no act of terror will go unpunished. “Surgical strikes post-Uri and Balakot (terror attacks) have amply demonstrated our political and military resolve against terror. Any act of terror will not go unpunished,” Rawat added.The army chief also said there has been no intrusion by the Chinese in Ladakh’s Demchok sector. “There is no intrusion,” Rawat said on the sidelines of an event.His statement came amidst reports of Chinese soldiers crossing the Line of Actual Control (LAC) last week after some Tibetans hoisted Tibetan flags on the occasion of Dalai Lama’s birthday on July 6.”Chinese come and patrol to their perceived Line of Actual Control…we try and prevent them. But at times there are celebrations that take place at the local levels. Celebrations were going on our side by our Tibetans in the Demchok sector. Based on that, some Chinese also came to see what was happening. But there has been no intrusions. Everything is normal,” the Army chief had said.READ | No intrusion by Chinese in Ladakh’s Demchok, says Army chief Bipin RawatWATCH | Army general exposes Pakistan’s lie on terrorFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySumeda Tags :Follow India Pakistan Let there be no doubt: No act of terror will go unpunished, says Army chief General RawatArmy chief General Bipin Rawat has said the Indian armed forces are ready to defend the territorial integrity. “Let there be no doubt that misadventures will be repelled with a punitive response,” he said.advertisement Nextlast_img read more

India Russia hold talks to boost space cooperation

first_img Press Trust of India New DelhiJuly 13, 2019UPDATED: July 13, 2019 00:12 IST Dmitry Rogozin, Director General of Russia’s space agency ROSCOSMOS, and National Security Advisor Ajit Doval led the two sides in the meeting. (Photos: ANI)India and Russia held high-level talks here to elevate bilateral cooperation to the next level in the field of space, including assistance in India’s maiden human space flight mission ‘Gaganyaan’, according to Ministry of External Affairs.National Security Advisor Ajit Doval and Dmitry Rogozin, Director-General of Russia’s space agency ROSCOSMOS, led the two sides in the meeting held on Thursday.”There have been frequent contacts between the two space agencies to finalise the details of the Gaganyaan Mission, which will carry Indian astronaut to space in 2022, to coincide with India’s 75th anniversary of Independence,” an MEA statement said Friday.Russia has promised all assistance for India’s Human Space Flight Mission and details regarding cooperation for the Gaganyaan Mission were discussed, the statement said, adding it also offered support to India in participating in the International Space Station.Both sides agreed to take a strategic approach to elevate bilateral cooperation to the next level keeping in mind the special and privileged partnership and India’s priorities such as Make in India programme, the MEA said.Senior representatives of ROSCOSMOS, GLAVCOSMOS, Energia and Energomash were present from the Russian side. From the Indian side, ISRO Chairman and Department of Space Secretary K Sivan and the Director of the Human Space Flight Programme also attended the meeting.Cooperation in futuristic technologies including new space systems, rocket engines, propellants and propulsion systems, spacecraft and launch vehicle technology were also discussed.”The Russian side stated that they would like to see India participate in the International Space Station, and offered its full support for this purpose,” the statement said.Space has emerged as a key area of cooperation between India and Russia in the high technology sector. India shares robust cooperation with Russia in strategic areas of defence, nuclear and space.Also Read | Pakistan not invited by Russia for Eastern Economic ForumAlso Watch | India signs $5.43 Billion deal with Russia on S-400 missileFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan India, Russia hold talks to boost space cooperationRussia has promised all assistance for India’s Human Space Flight Mission and details regarding cooperation for the Gaganyaan Mission were discussed, the statement said, adding it also offered support to India in participating in the International Space Station.advertisement Nextlast_img read more