Century-old drug reverses signs of autism in mice

first_imgA single dose of a century-old drug has eliminated autism symptoms in adult mice with an experimental form of the disorder. Originally developed to treat African sleeping sickness, the compound, called suramin, quells a heightened stress response in neurons that researchers believe may underlie some traits of autism. The finding raises the hope that some hallmarks of the disorder may not be permanent, but could be correctable even in adulthood.That hope is bolstered by reports from parents who describe their autistic children as being caught behind a veil. “Sometimes the veil parts, and the children are able to speak and play more normally and use words that didn’t seem to be there before, if only for a short time during a fever or other stress” says Robert Naviaux, a geneticist at the University of California, San Diego, who specializes in metabolic disorders.Research also shows that the veil can be parted. In 2007, scientists found that 83% of children with autism disorders showed temporary improvement during a high fever. The timing of a fever is crucial, however: A fever in the mother can confer a higher risk for the disorder in the unborn child.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)As a specialist in the cell’s life-sustaining metabolic processes, Naviaux was intrigued. Autism is generally thought to result from scrambled signals at synapses, the points of contact between nerve cells. But given the specific effects of something as general as a fever, Naviaux wondered if the problem lay “higher up” in the cell’s metabolism.To test the idea, he and colleagues focused on a process called the cell danger response, by which the cell protects itself from threats like infection, temperature changes, and toxins. As part of this strategy, Naviaux explains, “the cells behave like countries at war. They harden their borders. They don’t trust their neighbors.” If the cells in question are neurons, he says, disrupted communication could result—perhaps underlying the social difficulties; heightened sensitivity to sights, sounds, and sensations; and intolerance for anything new that often afflict patients with autism.The key player may be ATP, the chief carrier of energy within a cell, which can also relay messages to other nearby cells. When too much ATP is released for too long, it can induce a hair-trigger cell danger response in neighboring neurons. In 2013, Naviaux spelled out his hypothesis that autism involves a prolonged, heightened cell danger response, disrupting pathways within and between neurons and contributing to the symptoms of the disorder.The same year, he and his colleagues homed in on the drug suramin as a way to call off the response. The medication has been in use since the early 20th century to kill the organisms that cause African sleeping sickness. In 1988, it was found to block the so-called purinergic receptors, which bind to compounds called purines and pyrimidines—including ATP. These receptors are found on every cell in the body; on neurons, they help orchestrate many of the processes impaired in autism—such as brain development, the production of new synapses, inflammation, and motor coordination.To determine if suramin could protect these receptors from overstimulation by ATP, Naviaux’s team worked with mice that developed an autism-like disorder after their mothers had been exposed to a simulated viral infection (and heightened cell danger responses) during pregnancy. Like children with autism, the mice born after these pregnancies were less social and did not seek novelty; they avoided unfamiliar mice and passed up the chance to explore new runs of a maze. In the 2013 paper, the researchers reported that these traits vanished after weekly injections of suramin begun when the mice were 6 weeks old (equivalent to 15-year-old humans). Many consequences of altered metabolism—including the structure of synapses, body temperature, the production of key receptors, and energy transport within neurons—were either corrected or improved.In the new study, published online today in Translational Psychiatry, the researchers found equally compelling results after a single injection of suramin given to 6-month-old mice (equivalent to 30-year-old humans) with the same autism-like condition. Once again, previously reclusive animals approached unknown mice and investigated unfamiliar parts of a maze, suggesting that the animals had overcome the aversion to novelty that’s a hallmark of autism in children. After the single injection, the team lowered the levels of suramin by half each week. Within 5 weeks most, but not all, of the benefits of treatment had been lost. The drug also corrected 17 of 18 metabolic pathways that are disrupted in mice with autism-like symptoms.Naviaux cautions that mice aren’t people, and therapies that are promising in rodents have a track record of not panning out in humans. He also says that prolonged treatment with suramin is not an option for children, because it can have side effects such as anemia with long-term use. He notes that there are 19 different kinds of purinergic receptors; if suramin does prove to be helpful in humans, newer drugs could be developed that would target only one or a few key receptors. The researchers are beginning a small clinical trial in humans of a single dose of suramin that they hope will be completed by the end of the year.The study is exciting, says Bruce Cohen, a pediatric neurologist at Akron Children’s Hospital in Ohio. “The authors have come up with a novel idea, tested it thoroughly, and got a very positive response after one dose.” He notes, however, that the mice with a few characteristics of autism don’t necessarily reflect the entire condition in humans. “Autism isn’t a disease. It’s a set of behaviors contributing to hundreds of conditions and resulting from multiple genes and environmental effects. Great work starts with a single study like this one, but there’s more work to be done.”last_img read more

SPORT-IND-BOARD 2 LAST

first_imgIndia:India:KL Rahul b Tiripano 0 M Singh c Mutombodzi b Chibhabha 31 A Rayudu b Chibhabha 19 M Pandey c Tiripano b Muzarabani 48K Jadhav b Muzarabani 19 MS Dhoni not out 19 A Patel c sub b Madziva 18 R Dhawan not out 1 Extras (LB-2, WD-11) 13Total (For 6 wickets in 20 overs) 168 Fall of wickets: 1-0, 2-44, 3-53, 4-90, 5-143, 6-164.Bowling: D Tiripano 4-0-35-1, N Madziva 4-0-34-1, T Muzarabani 4-0-31-2, C Chibhabha2-0-13-2, S Raza 3-0-18-0, G Cremer3-0-35-0. PTI AT ATlast_img

Sri Lanka hurting from India whitewash: what’s plaguing the islanders?

first_imgAbout this time last year, August 17 to be precise, Sri Lanka were celebrating a 3-0 whitewash over Australia. It was a memorable routing of a team that had done well in the island nation despite a forgettable overall record in the sub-continent.Life was looking sweet for the Sri Lankans, who were learning to move on without Mahela Jayawardene, Kumar Sangakkara, Tillekaratne Dilshan and Lasith Malinga – an exodus of the greats from the arena had left a massive void in their cricket. (Team India is a bunch of friends playing cricket together: Virat Kohli)One year later, Sri Lanka have been subjected to their worst nightmare. For many who have followed cricket in Asia, this whitewash at the hands of a resurgent India, was perhaps waiting to happen. Could the disaster have been averted? Perhaps not, given Sri Lankan cricket’s sorry state of affairs.This Indian team is virtually unbeatable in these conditions. New Zealand, England and Bangladesh tried hard, they had the resources to at least challenge Virat Kohli’s men but at the end of the day, they did not even come close. Only Australia threatened India’s supremacy but were outdone by a more desperate bunch of players. (Virat Kohli rates Mohammed Shami among top 3 pacers in the world)Sri Lanka were not always this bad. Far from it. Even two years ago, when India won their first Test series in that country, the hosts were competitive. They were down for the count in the first Test but bounced back to clinch a sensational victory from the jaws of defeat. India, who were keen to start their journey to the top of the Test rankings, had to grind hard to win the next two Tests in Colombo. And the team has not looked back since.advertisementReuters PhotoMeanwhile, Sri Lanka have struggled. Series defeats in England and South Africa either side of the whitewash over Australia hampered them further. A one-off Test against Zimbabwe proved to be a stiff challenge and the batsmen somehow held on to blaze down a record target to avoid humiliation.But India were always going to be a different cup of tea. Kohli was diplomatic when he said Sri Lanka have some “super-talented players.” That may well be the case but where is the will? (Shikhar Dhawan goes from Hong Kong vacation to man-of-the-series in historic triumph)Where is the real talent? As many as 24 teams play first-class cricket in Sri Lanka. Ten teams who played in the second division were accorded first-class status over the last one year alone. The standard of cricket was obviously compromised, possibly to appease the various factions of Sri Lankan cricket. Sri Lanka’s domestic players hardly play enough cricket and even when they do, the quality is nowhere close to the kind of domestic cricket their peers in India, England, Australia and South Africa are accustomed to.Former captain Arjuna Ranatunga, who led Sri Lanka to World Cup glory in 1996, said he does not even watch his team play anymore. “Sri Lanka Cricket and the manner in which it is being administered and managed is so disgusting that I don’t watch our national cricket anymore,” Ranatunga was quoted as saying by ‘Ceylon Today’. (Team India elated after historic Test series triumph: Reactions)Moreover, there seems to be no sign of the next big star from Sri Lanka. For years, they had been blessed with Sanath Jayasuriya, Aravinda de Silva, Ranatunga, Roshan Mahanama, Muttiah Muralitharan, Chaminda Vaas before the younger generation stepped in – today, they have some quality players but they do not seem to learn from their mistakes.In the course of the whitewash to India, so many of Sri Lanka’s batsmen got starts but they failed to capitalise. Patience and application were forgotten in the haste to stave off defeat.Then there is the over-reliance on Rangana Herath. He has been a champion bowler for Sri Lanka with 389 Test wickets but at 39, surely, he must be looking at a swansong. Angelo Mathews looks like a spent force while Dinesh Chandimal has failed to inspire as a leader of his men.Sri Lanka are better than this – their younger players have to take up the mantle and deliver. The likes of Dimuth Karunaratne, Upul Tharanga, Kusal Mendis and Niroshan Dickwella have to lead the way somehow. They are the future of Sri Lankan cricket and their roles become important in the face of their worst defeat at home in history.last_img read more

Fans Calling Out Urban Meyer For What He Keeps Doing Today

first_imgUrban Meyer upset on the sideline vs. Maryland.Ohio State quarterback Dwayne Haskins has been pretty great today. The starter is 15-for-26 for 271 yards and three touchdowns, a few of which have been gorgeous throws.And yet, in the red zone, Haskins hasn’t always been handed the reigns of the Ohio State offense.Urban Meyer has been known to design packages for other quarterbacks. It worked out pretty well for his national championship Florida Gators team that featured Chris Leak and a young Tim Tebow.Meyer appears to be trying to recreate some of that magic with Tate Martell in the Tebow role. Martell is a tremendous athlete, but he isn’t freshman year Tebow, and Haskins is probably a more gifted player than Leak.Urban Meyer got criticized for his Tate Martell package earlier, and after Ohio State just settled for a field goal from the two, people are really piling on.Ohio State took a 27-19 lead on the kick, but that is still just a one score game vs. a very good Michigan team.Despite Martell getting a number of opportunities as the quarterback near the end zone, he has not attempted a throw, and has not this year since the September win over Tulane, and he has just one rushing yard.Why Ohio State takes out an elite passing QB for a QB who they won’t have throw the ball at all is a mystery. News flash: Haskins is really good.— Jon Solomon (@JonSolomonAspen) November 24, 2018I have never really understood the point of the Tate Martell goal line package.— Dan Wolken (@DanWolken) November 24, 2018Urban Meyer kicking a FG from inside the 2 yard line is the sort of gaffe that can cost them a conference title.— Jeff (BPredict) (@BPredict) November 24, 2018This Tate Martell red zone experiment has backfired. Again. Ohio State settles for a field goal for second straight time inside the 5. Buckeyes lead 27-19, but have left the door open.— Pete Thamel (@PeteThamel) November 24, 2018They gonna leave Martell out there for the FG too?— Anthony Lima (@SportsBoyTony) November 24, 2018The offensive play calling on this spot of the field has been weird for Ohio State today. Dwayne Haskins moves them all the way down to that spot, and then he come out… why? Make Michigan guess or something.— Kevin McGuire (@KevinOnCFB) November 24, 2018interesting decision by ohio state to put their “he never throws” quarterback in against the best defense in america, which somehow knew what was coming— Bill DiFilippo (@billdifilippo) November 24, 2018[dusts off old “let Justin Fields actually throw the ball maybe” tweets, replaces “Justin Fields” with “Tate Martell”]— Bill Connelly (@SBN_BillC) November 24, 2018If Ohio State wins, it will be a small part of the story about this game. It really feels like he should trust Haskins and his other playmakers near the end zone though.In some games, there may be spots where Martell works. Against this stout Wolverines team though, it doesn’t seem to be happening.last_img read more

Government Invests in New Bedford Arena

first_img FOR BROADCAST USE Halifax Regional Municipality residents are closer to enjoying a new four-rink arena in their community. The province confirmed today (November 17th) a two- million-dollar commitment to fund a new four-rink arena in Bedford. The arena is scheduled to be completed next year. Health Promotion and Protection Minister Maureen MacDonald says the project will provide more opportunities for local residents to live healthier and more active lives. The Department of Health Promotion and Protection will provide the funding from its Building Facilities Infrastructure Together (B-FIT) program. Under B-FIT, the province has committed over 63-million-dollars to 36 major infrastructure projects, generating more than 200-million- dollars worth of construction. -30- Halifax Regional Municipality residents are closer to enjoying a new four-rink arena in their community. The province confirmed today, Nov. 17, a $2-million commitment to fund the four-pad arena in Bedford, on the Hammonds Plains road. It is scheduled to be completed in 2010. “I am pleased the province is able to contribute to this new facility,” said Maureen MacDonald, Minister of Health Promotion and Protection. “The arena will provide more opportunities for local residents to live healthier and more active lives.” Halifax Regional Municipality requested funding from the province to help pay for the $42-million complex. The Department of Health Promotion and Protection will provide the funding from its Building Facilities Infrastructure Together (B-FIT) program. The program, launched in 2007, provides funds to replace, and upgrade recreation facilities in Nova Scotia. Under B-FIT, the province has committed more than $63 million to 36 major infrastructure projects, generating more than $200 million worth of construction.last_img read more

Nelson If the Iranian trip wasnt right chief tell me whats your

first_imgAPTN National newsFormer Roseau River First Nation chief Terry Nelson’s trip to Iran created controversy in Canada.During his trip, Nelson spoke on Iranian television comparing reserves to concentration camps and claimed North America denied a “holocaust” was committed against Indigenous people.Nelson sat down with APTN National News host Cheryl McKenzie to discuss his trip.Nelson: If the Iranian trip wasn’t right, chief tell me what’s your planlast_img

Ontario retailers acting rationally to minimum wage hike CoucheTard CEO

first_imgMONTREAL – Most Ontario retailers are acting rationally in response to January’s large increase in the minimum wage and not cutting hours of operations, the CEO of Alimentation Couche-Tard Inc. said Tuesday.“Maybe it’s a bit early to call it, but we think economics are prevailing and that these costs are being covered by increased sales and margins in Ontario,” Brian Hannasch said during its quarterly conference call.Even though the nearly 21 per cent increase in the province’s minimum wage was the largest he’s seen in his career, Hannasch said the company is working on strategies to offset those costs and remain competitive.The Ontario government’s decision to boost its minimum wage to $14 per hour this year and to $15 in 2019 has been criticized by business groups that claim it will force employers to hire less and increase automation.Couche-Tard’s shares sustained the largest decrease in at least two years after the convenience store operator widely missed analysts earnings expectations as its third-quarter results were hurt by lower U.S. fuel profits and the lingering impact from last fall’s hurricane Harvey.The shares closed down 6.45 per cent to C$59.60 in Tuesday trading on the Toronto Stock Exchange. That exceeds the 6.02 per cent decrease in February 2016.The Quebec-based convenience store retailer, which keeps its books in U.S. dollars, said its net earnings attributable to shareholders surged about 62 per cent to $463.9 million as acquisitions and a $182.2 million net tax benefit from the U.S. corporate tax cut offset challenges in the quarter.That equalled 82 cents per diluted share, compared with 50 cents per share or $287 million a year earlier.Excluding the tax benefit and other one-time items, its adjusted profit increased marginally to $304 million or 54 cents per share.Revenue for the 16-week period ended Feb. 4 totalled $15.79 billion, up from $11.42 billion.Analysts on average had expected a profit of 74 cents per share and revenue of nearly $15.63 billion, according to Thomson Reuters.Hannasch said its network in Europe, Canada and the acquired CST Brands sites experienced improving trends from higher same-store fuel volumes, merchandise revenues and in-store gross margins.But the U.S. fuel margin decreased 17 per cent to 15.66 cents per gallon driven mainly by the volatility from a rapid rise in crude oil prices particularly in Arizona and Texas.“So we view that as an anomaly,” he told analysts.“Could it recur? Yes. But over longer periods of time we think we’ve got a very competitive cost structure in the southwest part of the United States and that will fare well for us over longer periods of time.”Same-site fuel volumes declined 0.4 per cent in the U.S. as Texas was impacted by stores still recovering from hurricane Harvey. Increased pre-tax expenses caused by hurricanes totalled $1.8 million.Derek Dley of Canaccord Genuity attributed 17 of the 19 cents per share earnings miss in the quarter to softer-than-expected fuel margins.He estimates that the decrease in the 2019 U.S. corporate tax rate to between 17 and 19 per cent could add four- to eight-cents per share to its full-year EPS estimate.While tepid U.S. gas volumes and margins were the biggest surprise in the quarter, Irene Nattel of RBC Capital Markets remains positive about Couche-Tard, “particularly given the tailwind of recently closed CST and Holiday Stationstores acquisitions.”The company said it has converted more than 2,500 stores in North America and more than 1,450 in Europe to its new Circle K brand. It has started to convert the Mac’s brand in Canada. The brand will be featured everywhere except Quebec, where the Couche-Tard name will remain.Alimentation Couche-Tard has 12,750 stores and 15,970 locations, including those licensed under the Circle K brand and those that are part of last year’s merger with wholesale fuels distributor CrossAmerica Partners LP.Follow @RossMarowits on Twitter.Companies in this story: (TSX:ATD.B)last_img read more

Picture of Selena Gomez in Abu Dhabi Mosque Stirs Controversy

Rabat-  American actress and singer Selena Gomez has caused outrage and anger on social media after posting on Instagram an offensive photo showing her ankle inside the Sheikh Zayed Grand Mosque in Abu Dhabi. The photo, which has since been taken down, shows her posing in a black Abaya, the special dress for Gulf women, with a man wearing Arabian clothing.The American singer has been under fire following the‘disrespectful’ photos she posted on her Instagram with her friends, as part of their celebration of the New Year in Dubai.  The pop star also posted a video showing her and some friends eating an Arabian traditional dish, with a statement that reads, “this is how we eat here.”According to TMZ, the mosque leaders found the pose “disrespectful,” adding that the American singer did not respect the Mosque rules, which prohibit “laughing and smiling.”The leaders of the Sheikh Zayed Grand Mosque said that “modest, conservative, loose fitting clothing” are among the requirements to visit the mosque, adding that women must wear modest clothes that are “ankle length.” read more

California city approves 25cent fee on disposable cups

SAN FRANCISCO — Patrons of restaurants and coffee shops in Berkeley, California, who don’t bring a reusable cup for their beverage will have to pay a 25-cent fee for a disposable cup as part of an ordinance approved by city officials to eliminate restaurant waste.Berkeley’s City Council voted unanimously Tuesday to approve the fee on single-use cups, which will take effect January 2020.“The goal is to transition Berkeley from throwaway to reusable food ware, to incentivize people to bring their own cup,” said Councilwoman Sophie Hahn, who proposed the ordinance with Mayor Jesse Arreguin.Restaurants would keep all proceeds, and it would be up to them to decide what to do with the extra money, Hahn said. She said it could be invested on more environmentally friendly food ware.The ordinance also requires restaurants to provide takeout containers that are compostable by mid-2020 and to provide only reusable plates and utensils for those eating in. It also says other disposable items, like lids and stirrers, can only be offered when requested.The single-use cup fee is the latest effort in the socially forward city to reduce waste. Bans on plastic bags received support in the city of 100,000 long before California imposed its own ban in 2014.Berkeley pioneered recycling in the 1970s, but that alone is no longer enough, Hahn said.“We were the first city in the U.S. to do curbside recycling, and people thought we were crazy,” she said “But we pioneered that, and it has become the norm across the world.”Berkeley voters also became the first in the country to approve taxing sodas to curb consumption, after costly campaigns by the soda industry helped defeat similar taxes in more than 30 other cities and states in recent years.___Information from: KNTV-TV.Olga R. Rodriguez, The Associated Press read more

Kariyawasam reelected to UN Committee on Migrant Workers

Sri Lanka’s Ambassador to the USA, Prasad Kariyawasam, who has been a member of the UN Committee on Migrant Workers since its inception in March 2004, and the first Chair of the Committee , was re-elected for the fourth time at the Election held at the UN in New York on 28 June 2017, at the 8th Meeting of State Parties to the International Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families.The 51 States Parties to the Convention voted yesterday to select 7 members to the Committee, out of 11 candidates, for the period 2018-2021. The 11 candidates were from Albania, Argentina, Azerbaijan, Bangladesh, Burkina Faso, Colombia, Mali, Niger, Philippines, Senegal and Sri Lanka. Ambassador Kariyawasam’s re-election to the Committee for successive terms signifies the endorsement by the States Parties of his competence and contribution to the work of the Committee in promoting the human rights of migrant workers, and recognition of Sri Lanka’s role in this regard as well, on the international stage.Today, migrant workers account for a substantial component of the world’s approximately 250 million international migrants. Migrant workers around the world make a significant contribution to the growth and development of their countries of destination, and also to the improvement of the economies of their countries of origin through remittances. However, migrant workers are often vulnerable to exploitation and human trafficking. The Convention seeks to prevent and eliminate the exploitation of migrant workers throughout the migration process and promote a rights based approach to migration with a view to protecting the rights of migrant workers and members of their families. Sri Lanka’s candidate, Prasad Kariyawasam, was re-elected, securing the third highest number of votes, along with candidates from Albania, Azerbaijan, Bangladesh, Colombia, Senegal, and Niger. The UN Committee on Migrant Workers (CMW), consisting of a total of 14 elected members, as its main responsibility, monitors the implementation of the Convention, which is the most comprehensive international instrument that deals with the rights of migrant workers. The Convention which came into force in 2003, is an important component of the core international human rights treaties in the UN Human Rights Treaty System. read more

Pothole menace angers motorists creates business for repair shops

MONTREAL – An annoying sign of spring — the dreaded pothole — is testing the patience of Canadian drivers this year while also creating a financial bonanza for auto repair shops.Extreme fluctuations in early spring temperatures along with lots of rain have unearthed a high number of potholes that are exposing motorists to hefty repair bills.“It’s probably the worst year I’ve seen in the last 10 to 15 years,” Ben Lalonde, president of My AutoPro service centres in Ottawa, said in a recent interview.Business is up as customers are showing up with bent wheels, punctured tires, misalignments and wrecked suspensions. Repair bills can range between $200 and $500 depending on the force of impact and the type of damage, Lalonde said.Spring is a lucrative period for repair shops, says Jack Bayramian, owner of Montreal’s Decarie Garage, who adds that repairs stemming from pothole damage makes up about 30 per cent of his year’s revenues.There’s no tally for the cost of dealing with the aftermath of potholes in Canada, but a poll of U.S. motorists by the American Automobile Association suggests they spend an average of US$3 billion a year dealing with pothole repairs. The Canadian Automobile Association is in the process of conducting its own poll.While repair shops welcome the extra business, they also say it can cause customers to pare back spending on preventative maintenance.“I know having bad roads is good for business but I think it’s (temporary) … because a lot of people end up neglecting their cars, and at the end it could be a safety concern,” James Bastien, manager of an OK Tire in the nation’s capital.Most motorists tend to pay for repairs out-of-pocket unless damage is well above insurance claim deductibles, or they can beat the odds and win a claim from a municipality.Several large Canadian municipalities are struggling this year to keep up with the menace that is consistently among the top sources of angry complaints from residents.“This year has been fairly bad,” says Bryden Denyes, area manager of core roads for the City of Ottawa.The city has filled 51,000 potholes so far this year, up substantially from 20,200 at the same time in 2015, but down slightly from two years ago. Compared to last year’s almost relentless bone-chilling cold, Ottawa has faced 28 freeze-and-thaw cycles versus just 11 a year ago.The capital spends $5.4 million a year filling potholes and repairing roads, compared to the nearly $7 million to fix major and arterial roads in Montreal. Toronto spent $6 million in 2014 to fix 360,000 potholes.Lionel Perez, a councillor responsible for Montreal’s infrastructure, said it’s a constant struggle to plug the holes, especially because of decades of under-investment.The challenge is even bigger in Edmonton, which over the last nine years has faced an average of 455,000 new potholes a year. A warmer winter and less snow has given the Alberta capital somewhat of a reprieve this year.In addition to filling potholes, municipalities have to contend with damage claims submitted by residents.Very strict rules limit compensation in Quebec. Payouts are also low in other provinces.Ottawa paid out only 10 per cent of claims last year, while Edmonton’s annual payout ratio is about 16 per cent. Toronto, meantime, paid out about half the 2,376 claims filed in 2014, the city said in its latest report. Pothole menace angers motorists, creates business for repair shops A pothole is seen on St. Paul street Friday, March 18, 2016 in Montreal. An annoying sign of spring — the dreaded pothole — is testing the patience of Canadian drivers this year while also creating a financial bonanza for auto repair shops. THE CANADIAN PRESS/Ryan Remiorz by Ross Marowits, The Canadian Press Posted Mar 28, 2016 2:00 am MDT Last Updated Mar 28, 2016 at 7:00 am MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email read more

Football The difference in Ohio States offense moving forward could be Mike

Ohio State redshirt sophomore running back Mike Weber (25) runs the ball in the first half in the game against Illinois on Nov. 18. Ohio State won 52-14. Credit: Jack Westerheide | Photo EditorOhio State shouldn’t have needed a 30-point loss to a team that just lost at home to Purdue to know it needed to run the ball more.The Buckeyes have two of the best running backs in the Big Ten, and for some reason it took an embarrassing loss at Iowa for head coach Urban Meyer to figure out that J.K. Dobbins and Mike Weber should touch the ball 30-plus times combined each game.It wasn’t surprising the Buckeyes went back to the ground game after being trounced against an inferior opponent, but Weber’s play has been surprising, and it’s what makes Ohio State’s offense even more dangerous moving forward.“If you can get the running game going, put a guy on a guy and execute pretty highly,” center Billy Price said, “then our running backs are lights-out speed, get out in open space, then good things happen.”Weber started the scoring against Michigan State with a 47-yard touchdown run, then topped that with an 82-yarder. The thought was: Maybe Weber is finally healthy and this is a running back that can hit long runs for scores.He scored twice Saturday in a 52-14 drubbing of Illinois. One was another long touchdown run of more than 40 yards.That thought of “Is this a new Mike Weber?” has additional supporting evidence, which would give Ohio State two legitimate homerun threats at running back.So why wasn’t he running like this before?“Weber is just 100 percent healthy,” Meyer said. “We were bragging about him all summer and then had the tough injury. But he’s doing very well.”Meyer said last week that Weber’s hamstring injury was severe enough to consider surgery. So maybe he truly is finally healthy and that’s what is making the difference in his game and perceived improved quickness since the Iowa game.No one has really been able to figure out Ohio State’s colossal conundrum against the Hawkeyes.“What just happened,” has been a repeating question for three weeks. Meyer raised it after a fourth-quarter comeback against Penn State. Fans and media asked it following a complete collapse against Iowa the week after, then it came up again in an annihilation of Michigan State the week after that.Still, no one really has a good answer for the Iowa game, especially after the blowout of a ranked Michigan State. Maybe fans can just chalk it up as an unexplainable letdown and hope that Ohio State team doesn’t show up again because this Ohio State team that clobbered Michigan State and kicked the snot out of a terrible Illinois team is pretty good — maybe playoff good.Weber is a major part of that.“If we get the running game going, everything else opens up,” Price said.Meyer and the offensive coaching staff have talked all year about the possibility of playing both Weber and Dobbins in a formation. That’s now possible. And what a better week to do that than against Michigan.Weber is averaging 13.5 yards per carry the past two games and has gained more than 100 yards in each. The offensive line has been making its case as one of the best units in the country, but the running backs are doing their job, like they have been all year.Weber’s production in the past two games is unequivocal to the first nine games, and it’s a welcomed addition.Meyer and the coaching staff somehow didn’t see the writing on the wall that the running game was always the team’s identity. But that gaffe by the staff might not matter because Ohio State is in the playoff picture, and if Weber’s performances the past two games are an indicator of a new Weber, he can make this offense College-Football-Playoff good. read more

Pothole related breakdowns soar following harsh winter

first_img Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings. “While RAC patrols saw the third highest quarterly share of pothole-related breakdowns in the first three months of 2018, the figure was not as high as we had been expecting, probably due the fact that the weather hit relatively late in the quarter.”For this reason we feel we are likely to see more vehicles suffering pothole damage in the second quarter of 2018 compared with recent years.”The Government has made additional funding available through yet another emergency pothole fund, but at best this will only allow councils to patch up roads that in many cases are in desperate need of longer term preventative maintenance.”A Local Government Association spokesman said: “When exceptional weather occurs, the impact on local roads can be significant.”It’s essential this is measured and that funds are provided for serious repairs so that traffic can move freely through our communities, and local economies and businesses aren’t impacted.” Pothole related breakdowns have doubled in the space of three months following the harsh winter, the RAC has revealed.The breakdown rescue firm said the proportion of call-outs caused by issues such as damaged shock absorbers, broken suspension springs and distorted wheels reached 2.3 per cent between January and March.This is almost double the rate during the previous three months and equates to 5,540 cases.Since RAC records began in 2006, only two three-month periods – January to March in both 2015 and 2017 – saw a higher proportion of pothole-related breakdowns.A better indicator of the true state of the UK’s roads is expected to be revealed in figures for April to June as the Beast from the East brought snow and freezing weather towards the end of the previous quarter.RAC chief engineer David Bizley said: “Anecdotally, few would disagree that the harsh cold weather experienced over the last three months has led to a further deterioration of road surfaces.last_img read more

2 killed as minibus turns turtle on ECD Highway

Two women were on Sunday morning killed when the minibus in which they travelling collided with a motorcar and toppled several time before crashing into a median at Success Public Road, East Coast Demerara. Several others were injured as a result of the collision.Dead are 58-year-old, Denise Cully of Lot 89 Vigilance, East Coast Demerara (ECD) who was reportedly flung out of the bus and  Patricia Ellis, 59, of Lot 30 Haslington, East Coast Demerara (ECD). She died while receiving medical treatment at the Georgetown Public Hospital. Corporation (GPHC).Those injured are Jaden Miffatt, 7, a student of Golden Grove Primary School, East Coast Demerara (ECD), Laffanna Williams, 22, of Lot 175 Haslington, June Abel, 60, of Lot 8 Good Hope, Wayne Blair, 38, of Lot 38 Fernandez St. Golden Grove and Jordon Beaton, 17, of also of Golden Grove.<<>> understands that at about 7:30h, the minibus BTT 4910 was proceeding west along the southern carriageway of the Success Road when a motorcar which was attempting to overtake slammed into the left rear of the bus causing the driver, to lose control crashing into a medium bar.The minibus then turned onto its side reportedly landed on Cully. The vehicle then skidded for some distance before coming to a halt.Public spirited persons assisted by turning over the minibus on its wheels when Cully’s lifeless body was pulled from underneath. Several other passengers were rushed to the hospital where they are being treated, Ellis died while receiving treatment.Beaton who reportedly lost several fingers in the accident was rushed the Woodlands hospital where he underwent surgery. A breathalyzer test conducted on the driver showed no trace of alcohol on his breath. He was however, taken into Police custody where he is assisting with investigations.Investigations into the accident is continuing. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedDriver remanded after women die in bus crashMarch 5, 2019In “Court”Two injured in accident on Golden Grove public roadFebruary 1, 2018In “Crime”Man dead, US based brother critical in ECD smash upJuly 5, 2014In “Crime” read more

Samesex marriage in Utah put on hold by US Supreme Court

first_imgTHE UNITED STATES Supreme Court has put same-sex marriages on hold in Utah while a federal appeals court more fully considers the issue.The court issued a brief order this afternoon blocking any new same-sex unions in the state.The order follows an emergency appeal by the state for a ban after the December 20 ruling by U.S. District Judge Robert Shelby that the state’s ban on same-sex marriage violates gay and lesbian couples’ constitutional rights.More than 900 gay and lesbian couples have married since then.The high court order will remain in effect until the Denver-based 10th U.S. Circuit Court of Appeals decides whether to uphold Shelby’s ruling.Immediate haltLate last week, Supreme Court Justice Sonia Sotomayor was considering Utah’s request to put an immediate halt on gay marriages in Utah.It followed legal arguments before the U.S. Supreme Court about the state’s previously overturned same-sex marriage ban have focused heavily on whether gay and lesbians can be suitable parents, provoking a debate on family values in the Mormon state.Lawyers for the state set the tone for the debate in a 100-page filing with the high court this week that made several references to their belief that children should be raised by straight couples.An attorney for same-sex couples says the state’s argument has no scientific backing and that denying gays and lesbians the right to marry actually causes severe harm to their children.Read: Gay marriage was legal in Utah for the weekend but a ban could return today >More: Coca-Cola Ireland in hot water on Twitter for removing gay marriage scene from Irish advert >last_img read more

Old Boy hero honoured

first_imgOn Sunday 25 October 2015, the co-ordinating committee of Pontian Associations for the Genocide of the Greeks of Pontos organised an expedition to Ballarat in order to lay a plaque and plant an olive tree at St Patrick’s College in honour of George Treloar.George Treloar, a former student of St Patrick’s College, had been instrumental in assisting more than 100,000 Greeks of Pontos to settle in northern Greece after their uprooting from Pontos as a result of the 1922 Asia Minor disaster.In its journal The Shamrock, Volume 14, December 2015, St Patrick’s College published the following account of the above-mentioned event under the title ‘Old Boy hero honoured’, with the accompanying photographs.“One of Ballarat’s greatest unsung World War I heroes has finally been honoured in his home town with the installation of a plaque and the planting of an olive tree in his honour at St Patrick’s College.George Devine Treloar was a Military Cross medal winner for his heroic actions on the Somme and at Ypres, yet it was his post-war deeds for which he has been remembered across the world as a man who saved hundreds of thousands of lives.At the end of World War I Major Treloar (SPC 1900) dedicated his time to working with the British Mission, helping resettle displaced families. Major Treloar worked voluntarily for two years assisting Russian, Armenian and Assyrian refugees and was awarded several prestigious Russian military honours for his efforts.Then, from 1922-1926, Major Treloar was appointed as a representative of the League of Nations High Commissariat for refugees in northern Greece and was responsible for the resettlement of 108,000 Pontian Greek refugees.For his humanitarian efforts, he was awarded the Order of the Redeemer (gold cross) and the Greek village of Thrilorio has been named in his honour. Australian-based descendants of the Pontian Greek community have this year sought to honour the man they consider the hero of their people and contacted St Patrick’s College to ensure the Ballarat community was aware of Major Treloar’s incredible deeds.On Sunday October 25, around 70 descendants of refugees who were saved by Major Treloar attended a luncheon at St Patrick’s College and participated in a plaque-laying and tree-planting ceremony.Chairman of the Commemoration Committee for the Pontian Greeks Mr Kostas Antoniadis announced at the ceremony that an annual scholarship of $500 would be presented in Major Treloar’s honour to a St Patrick’s College student who worked tirelessly for the good of the wider community, as George Treloar had done a century ago.“Such men are sculpted with such strong convictions from a young age and Major Treloar’s schooling must have played a major role in making the man he became,” Mr Antoniadis said.“He has since passed on but his alma mater still exists and we wish to pay respects to him and St Patrick’s.”St Patrick’s College headmaster Mr John Crowley said the college was delighted to be able to honour such an esteemed Old Collegian and hoped the laying of the plaque would help inform the wider Ballarat community about George Treloar’s bravery and community compassion.“At St Patrick’s College our aim is to raise fine boys to the status of great men and it is clear that Major George Treloar was indeed a great man,” Mr Crowley said.“He is a hero of many nations, a man responsible for saving thousands of lives, all done with compassion and care for the individual.“We are delighted to welcome to St Patrick’s College descendants of those who Major Treloar cared for, and are excited that his name will live long in the history of St Patrick’s College through the initiation of the George Treloar Scholarship.” Facebook Twitter: @NeosKosmos Instagramlast_img read more

Stabbing Draws Attention to People Living in Balboa Park

first_img Posted: August 6, 2018 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – The fatal stabbing of a man in Balboa Park has drawn attention to the people who are sleeping in San Diego’s most famous park and calling it home.Michael Klausing knows where the homeless live, because he’s one of them. He showed us the part of the park where the stabbing occurred and said he also knew the victim and the man accused of killing him, because like him, they were also living in Balboa Park.People who need more shelter aren’t just living on city streets. They’re also taking up residence in the city’s most beautiful park, under the trees and in the canyons.The open space is one attraction. So are the public restrooms that are open 24 hours a day. They’re a necessity for people who don’t have any other access to a toilet or a sink where they can wash up and try to keep themselves clean. Keeping the restrooms clean is another matter. Michael was as disgusted as we were to find a toilet in one restroom, clogged and overflowing with waste. Crews who work for the city’s Department of Parks and Recreation told us they routinely clean the park bathrooms four times a day, but clogged toilets are a daily occurrence. Maintenance workers said it was common to find the toilets stuffed with too much paper, cans or even clothing.Some visitors to the park have taken note. On the travel website “Tripadvisor,” 95% of the reviews of the park were positive, but we did find a few postings like this one; “I found there were a lot of homeless people hanging around and people exchanging drugs.”Camping in the city park is against the law, but it appears many people are living there, either in tents or under tarps. When we asked Michael, why did he think so many people were settling in, he told us, “I don’t know why more and more people are coming here Because they think it’s easier to stay here? I don’t know.”We asked the San Diego Police Department and the city’s Parks and Recreation Department to talk to us about the challenges of managing unsheltered people who are living in the park. A spokesperson for the Parks Department sent us a statement regarding the recent stabbing. The statement reads, “In light of the recent incident in the park this past weekend, rangers and park staff will remain diligent and continue to patrol park grounds and facilities and notify SDPD of any public safety concerns that may arise.” Sasha Foo, August 6, 2018 Sasha Foo Stabbing Draws Attention to People Living in Balboa Park Categories: Local San Diego News FacebookTwitterlast_img read more

Teen Play Explores The Complexities Of Date Rape

first_imgJuneau-Douglas High School seniors Robert Newman and Brita Fagerstrom star in the play “Hush.” (Photo by Lisa Phu/KTOO)Five Juneau teens star in a play about the complexities of date rape. The show is called “Hush,” but the teens hope the audience do exactly the opposite.Download Audio“And I could’ve said something, you know. I mean, I said no, but I could’ve said something else or fought harder or fought even more or, I don’t know, something like that …”Brita Fagerstrom rehearses the role of Kim Tuesday night at Juneau-Douglas High School. Kim’s been raped by her boyfriend and consequently deals with depression and getting her life back together.Fagerstrom hopes the message about consent in the play is clear.“No means no. It shouldn’t have to be a struggle. It shouldn’t have to be some crazy loud act. Even just saying no in a whisper, anything like that,” she says.Demaris Oxman, who acts the roles of a parent and therapist, says the play explores how consent often gets muddled in a relationship.“Rob, Kim’s boyfriend in the play, says, ‘We were fooling around and she may have said that she said no, but I knew what she really meant.’ And I feel like it kind of shows that some people in our culture really do think that somebody has a right to do whatever they want if they’re already together, like that’s a form of consent, but it’s not,” Oxman says.Robert Newman plays Rob, a character confused about what he’s done and isn’t sure how to deal with the guilt or losing his friends. Newman says Rob isn’t a monster.“It’s any person, any person who doesn’t listen to their partner can fall into this role. And that’s something we really got to teach our generation,” Newman says.Ashleigh Watt and Max Blust play the Kim’s best friends in “Hush.” (Photo by Lisa Phu/KTOO)For a group of actors who are used to performing in musicals and comedies, “Hush” was challenging and personal.Oxman says she had to sub in as Kim’s best friend during a short performance last weekend.“It was very intense because I had to think about how would I react if this happened to my best friend or to me, and then it became very real,” she says.Ashleigh Watt, who plays the best friend, says people sometimes don’t realize they’ve been raped or are in denial.“We see things like this all the time, where to some degree something like this happens, and a lot of times people just ignore it and that’s not OK,” Watt says.Director Michaela Moore says as a teacher and a parent, she’s heard and dealt with a lot of heartbreaking things having to do with partners not being respectful.“I just really hope that kids will come [to the play] so they can begin to talk about these things, and girls, especially, can realize it is their right to give consent or not give consent, and that they need to stop letting boys have such power over their life,” Moore says.She hopes the play makes people feel uncomfortable. Fagerstrom says it will make an impact.“This show is kind of jarring. It’s putting it in your face and the reason it’s called ‘Hush’ is because it’s a topic you don’t talk about, but this show is about talking about it. It’s about opening up a conversation with the community about it,” Fagerstrom says.Everyone needs to part of the conversation — children, teenagers, adults — so it’s out in the open. If not, she says, then sexual assault and date rape will continue to happen.“Hush: A Play About the Complexities of Date Rape” will be performed Friday and Saturday at 7 p.m. @360, 360 Egan Drive.last_img read more