Nature changes animal policy after cancer study comes under fire

first_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country The journal Nature is revising its policy on publishing animal experiments after a study it ran in 2011 received criticism because the authors allowed tumors to grow excessively large in mice. The paper reported that a compound isolated from a pepper plant killed cancer cells without harming healthy cells.Yesterday, the journal published a correction to the study (the paper’s second), which noted that “some tumors on some of the animals exceeded the maximum size … permitted by the Institutional Animal Care and Use Committee.” The tumors were only supposed to grow to a maximum of 1.5 cubic centimeters, but some reached 7 cubic centimeters, according to David Vaux, a cell biologist at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, who first raised concerns about the paper in 2012. (Vaux spoke to Retraction Watch, which first reported the correction.)In an editorial published yesterday, Nature calls the large tumors “a breach of experimental protocol,” one that could have caused the mice to “have experienced more pain and suffering than originally allowed for.” The journal also noted the lapse could have implications beyond the one study, saying that “cases such as this could provoke a justifiable backlash against animal research.” Email Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwecenter_img Nature says it will now require authors to include the maximum tumor size allowed by its institutional animal-use committee, and to state that this size was not exceeded during the experiments. The journal does say, however, that it is not retracting the paper, and that the study remains “valid and useful.”   Science Executive Editor Monica Bradford says that during the manuscript submission process, authors must agree to a list of conditions, one of which is that experimental animals have been handled in accordance with the authors’ institutional guidelines. Furthermore, she says, if during the evaluation of a manuscript, a reviewer requests more information about the handling of experimental animals, Science’s editorial team will follow up with the authors to satisfy the reviewer query. Click to view the privacy policy. Required fields are indicated by an asterisk (*)last_img read more